Evidence map›Paper›PMID 40494938›Full record

ArticleNature cancer2025

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response.

Jinpeng Han, Shenqiang Wang, Weifeng Fang, Yinxian Yang, Ruyi Zhou, Yuqi Zhang, Jicheng Yu, Ruikang Tang, Zhaoming Liu, Zhen Gu

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinpeng Han *State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0003-4443-4671
Shenqiang Wang *State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0001-8579-6367
Weifeng Fang *Department of Chemistry, Zhejiang University, Hangzhou, China.
Yinxian YangState Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-2296-7111
Ruyi ZhouState Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China.
Yuqi ZhangState Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China.
Jicheng YuState Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China.
Ruikang TangDepartment of Chemistry, Zhejiang University, Hangzhou, China. rtang@zju.edu.cn.ORCID http://orcid.org/0000-0001-5277-7338
Zhaoming LiuDepartment of Chemistry, Zhejiang University, Hangzhou, China. oldliu@zju.edu.cn.ORCID http://orcid.org/0000-0002-7564-6207
Zhen GuState Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, School of Pharmacy, Zhejiang University, Hangzhou, China. guzhen@zju.edu.cn.ORCID http://orcid.org/0000-0003-2947-4456

Funding

China Postdoctoral Science Foundation 22435006École Nationale d'Ingénieurs de Saint-Etienne (National Engineering School of Saint-Étienne) 223B2504National Natural Science Foundation of China (National Science Foundation of China) 22435006National Natural Science Foundation of China (National Science Foundation of China) 52233013National Natural Science Foundation of China (National Science Foundation of China) 52303208
6 · The paper itself

Abstract

Long-acting controlled drug release formulations are highly desired for potentiating efficacy and reducing administration frequency. Here we present a kinetically controllable long-term interleukin-2 (IL-2) release platform by the fusion and boundary elimination of calcium carbonate and calcium phosphate amorphous phases. Unlike mixtures, a group of hybrid biominerals with the chemical formula Ca(CO

Indexed as

Antineoplastic AgentsInterleukin-2Melanoma, ExperimentalAnimalsCalcium CarbonateCalcium PhosphatesCell Line, TumorDelayed-Action PreparationsFemaleHumansMiceMice, Inbred C57BLPressureTabletsTumor MicroenvironmentAntineoplastic AgentsCalcium Carbonatecalcium phosphateCalcium PhosphatesDelayed-Action PreparationsInterleukin-2Tablets

Identifiers

PMID40494938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.