SynthesisNature human behaviour2025
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes.
Abstract readTwin StudyMeta-Analysis
In one paragraph
Synthesis in Nature human behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Neuropsychiatry genetics in Africa.Nature communications · 2026Review
- Challenges and future directions for Mendelian randomization.Nature genetics · 2026Review
- Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B.American journal of human genetics · 2026Article
- Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.Nutrients · 2025Article
- Exploring high dental anxiety subtypes using cluster analysis approach: a cross-sectional study.BMC oral health · 2025Article
Corrections and comments
- Update of
Authors and funding
53 authors.
Elham AssarySchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. elham.1.assary@kcl.ac.uk.ORCID http://orcid.org/0000-0001-9788-0478
Jonathan R I ColemanSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6759-0944
Gibran HemaniMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-0920-1055
Margot P van de WeijerDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-9720-9481
Laurence J HoweMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Teemu PalviainenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7847-8384
Katrina L GrasbyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-8539-0228
Rafael AhlskogDepartment of Government, Uppsala University, Uppsala, Sweden.
Marianne NygaardThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0003-0703-2665
Rosa CheesmanThe PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-6543-0402
Kai LimSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Chandra A ReynoldsInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Juan R OrdoñanaDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.ORCID http://orcid.org/0000-0001-7779-6017
Lucia Colodro-CondeQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-9004-364X
Scott GordonQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7623-328X
Juan J Madrid-ValeroDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.ORCID http://orcid.org/0000-0002-3450-1159
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-7114-1260
Jouke-Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-5668-2368
Jonas Mengel-FromThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0003-1573-8908
Nicola J ArmstrongCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-4477-293X
Perminder S SachdevCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Teresa LeeCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.
Henry BrodatyCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9487-6617
Julian N TrollorCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-7685-2977
Margaret WrightQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7133-4970
David AmesUniversity of Melbourne Academic Unit for Psychiatry of Old Age, St George's Hospital, Melbourne, Victoria, Australia.
Vibeke S CattsCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9892-0547
Antti LatvalaInstitute of Criminology and Legal Policy, University of Helsinki, Helsinki, Finland.
Within Family Consortium
Eero VuoksimaaInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Travis MallardDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3265-3001
K Paige HardenDepartment of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-1557-6737
Elliot M Tucker-DrobDepartment of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0001-5599-6237
Sven OskarssonDepartment of Government, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-8698-2866
Christopher J HammondDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3227-2620
Kaare ChristensenThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0002-5429-5292
Mark TaylorDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
Sebastian LundströmGillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-7235-8499
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-6851-3297
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-8949-2587
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.
Karen A MatherCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4143-8941
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Dorret I BoomsmaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Robert PlominSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-0756-3629
Meike BartelsDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9667-7555
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0003-3037-5287
Jaakko KaprioInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Thalia C EleySocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-6458-0700
Neil M DaviesDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0000-0002-2460-0508
Patricia B MunroeWilliam Harvey Research Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-4176-2947
Robert KeersSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
Funding
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0MColorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)R01AG046938 · NIA · UNIVERSITY OF COLORADO · PI REYNOLDS, CHANDRA A, WADSWORTH, SALLY J · 2015 to 2024
$18.5MTRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JOHNSON, THOMAS E. · 1990 to 2008
$17.5MThe development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6MCauses and consequences of mental disorders: The environmental and genetic influences of parents on offspring.R01MH130448 · NIMH · UNIVERSITY OF COLORADO · PI Matthew Charles Keller · 2022 to 2026
$3.7MClarifying risk and protective factors for dementia with the Interplay of Genes and Environment in Multiple Studies (IGEMS) consortiumR01AG060470 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2018 to 2022
$3.6MGene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2MADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9MSES health gradients in late life: testing models of gene-environment interplay in an international twin consortiumR01AG059329 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, BRIAN K., GATZ, MARGARET · 2018 to 2022
$2.9MGENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8MDEMENTIA IN TWINSR01AG008724 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET · 1990 to 2002
$1.4MTwin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3MEPA EP-C-15-001NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA012502NIA NIH HHS P01 AG008761NIA NIH HHS R01 AG008724NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG017561NIA NIH HHS R01 AG028555NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG046938NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG059329NIA NIH HHS R01 AG060470NIMH NIH HHS R01 MH130448Wellcome TrustWellcome Trust (Wellcome) 208881/Z/17/Z
Abstract
Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging to detect. Genome-wide association studies of monozygotic twin differences are conducted through family-based variance analyses, which are more robust to the systemic biases that impact population-based methods. We combined data from 21,792 monozygotic twins (10,896 pairs) from 11 studies to conduct one of the largest genome-wide association study meta-analyses of monozygotic phenotypic differences, in children, adolescents and adults separately, for seven psychiatric and neurodevelopmental phenotypes: attention deficit hyperactivity disorder symptoms, autistic traits, anxiety and depression symptoms, psychotic-like experiences, neuroticism and wellbeing. The proportions of phenotypic variance explained by single-nucleotide polymorphisms in these phenotypes were estimated (h
Indexed as
Gene-Environment InteractionMental DisordersNeurodevelopmental DisordersTwins, MonozygoticAdolescentAdultAttention Deficit Disorder with HyperactivityChildFemaleGenome-Wide Association StudyHumansMalePhenotypePolymorphism, Single NucleotideYoung Adult
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.