ArticleNPJ Parkinson's disease2025
L-Dopa-induced changes in aperiodic bursts dynamics relate to individual clinical improvement in Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Long-term reliability and stability of parameterized resting state EEG: evidence from a five-year follow-up.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Dynamic brain synergy uncovers functional neural coordination in Parkinson's disease under dopaminergic modulation.Journal of neuroengineering and rehabilitation · 2026Article
- The role of high-amplitude bursts of high-gamma activity in naturalistic speech and music listening.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- A meta-analysis of periodic and aperiodic electrophysiological features in Parkinson's disease.Brain communications · 2026Review
- The Virtual Parkinsonian patient.NPJ systems biology and applications · 2025Article
- The Effect of Dopaminergic Therapy in Parkinson's Disease: A Graph Theory Analysis.Brain sciences · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Parkinson's disease (PD) is a neurodegenerative disease characterized by severe motor symptoms, transiently alleviated by medication (e.g. levodopa), and widespread brain activity alterations that remain poorly understood at a large scale level. To address this issue, we used resting-state STN-DBS and motor EEG data from 11 PD patients before and after levodopa treatment. Neuronal avalanches, i.e., brief, widespread bursts of activities, were detected and compared across the two conditions. Interestingly, we noted shorter and smaller avalanches in the OFF-condition and fewer, longer, and larger avalanches in the ON-condition. We then computed the avalanche transition matrices to track the contact-wise patterns of avalanche spread. We found a significantly higher probability of avalanche spread within and between the STN and motor cortex in the ON-condition. Furthermore, increased propagation of avalanches correlated with clinical improvement. Our study identifies potential biomarkers for electrophysiological changes in PD through cross-modality assessment of aperiodic activities.
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Registered trials
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