Evidence map›Paper›PMID 40494847›Full record

ReviewCell death discovery2025

Cuproptosis and cuproptosis-related cell death and genes: mechanistic links to spermatogenic cell death.

Junjun Li, Nihong Li, Hong Wang, Bin Li, Xinyi Tang, Yanxin Guan, Fang Yang, Guangsen Li, Liang Dong, Renbin Yuan and 1 more

Abstract readReview
In one paragraph

Review in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Junjun LiChengdu Fifth People's Hospital/The Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID http://orcid.org/0000-0002-2956-9079
Nihong LiChengdu Fifth People's Hospital/The Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hong WangChengdu Fifth People's Hospital/The Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Bin LiZiyang Yanjiang People's Hospital, Ziyang, China.
Xinyi TangTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yanxin GuanTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Fang YangTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Guangsen LiTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Liang DongTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Renbin Yuan *TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. yuanrenbin123@163.com.ORCID http://orcid.org/0000-0002-7760-9231
Xujun Yu *School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China. yuxujun@cdutcm.edu.cn.ORCID http://orcid.org/0000-0002-5620-6783

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82274325
6 · The paper itself

Abstract

Spermatogenesis, which is regulated by multiple cell death mechanisms, is an extremely complex process. The significance of cell death during spermatogenesis is a topic of interest because of its potential medical implications. Cuproptosis is a new mechanism of cell death discovered in recent years, and recent studies have preliminarily confirmed that cuproptosis is involved in the process of spermatogenic cell death, but its specific role in the process of spermatogenic cell death is still unclear. In this review, the mechanisms of spermatogenic cell death associated with cuproptosis and the effects of key genes of cuproptosis on spermatogenesis are discussed together with some new perspectives for the study of spermatogenic cell death.

Identifiers

PMID40494847
PMCPMC12152130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.