Evidence map›Paper›PMID 40494815›Full record

ArticleACS applied materials & interfaces2025

Direct Laser Writing of Selectively Degradable Polypeptide Hydrogel Microstructures by Proteolytic Enzymes.

Yekaterina Tskhe, Viviane Chiaradia, Brian J Rodriguez, Larisa Florea, Colm Delaney, Robert D Murphy

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yekaterina TskheSchool of Chemistry, Trinity College Dublin, Dublin 2, Ireland.
Viviane ChiaradiaDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin D02 YN77, Ireland.
Brian J RodriguezSchool of Physics and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4 N2E5, Ireland.ORCID 0000-0001-9419-2717
Larisa FloreaSchool of Chemistry, Trinity College Dublin, Dublin 2, Ireland.ORCID 0000-0002-4704-2393
Colm DelaneySchool of Chemistry, Trinity College Dublin, Dublin 2, Ireland.ORCID 0000-0002-4397-0133
Robert D MurphyDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin D02 YN77, Ireland.ORCID 0000-0003-3147-3196

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery of materials with on-demand, tunable degradability is of significant utility for (micro)structures generated through additive manufacturing techniques. Disclosed here are a series of star polypeptide cross-linkers comprising either l-lysine alone or l-lysine and l-alanine residues for use in direct laser writing of hydrogel microstructures, which are selectively degradable via intrinsic amino acid affinities to different proteolytic enzymes. Through multimaterial printing, direct laser writing permitted the formation of microstructural topographies through free radical polymerization of formulated polypeptide cross-linkers and commercial photoresists, whereby sections of the microstructures could undergo selective degradation in the presence of target proteases, thermolysin, and trypsin.

Indexed as

HydrogelsLasersPeptidesThermolysinTrypsinHydrogelsPeptidesThermolysinTrypsindirect laser writingenzyme degradationhydrogelspolypeptidestwo-photon polymerization

Identifiers

PMID40494815
PMCPMC12203468

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.