Evidence map›Paper›PMID 40494812›Full record

ArticleHistopathology2025

Methylation analysis as a diagnostic tool for sweat gland tumours classification with emphasis on the distinction between digital papillary adenocarcinoma and mimickers.

Pierre Sohier, Nicolas Macagno, Anne Tallet, Coralie Mousset, Maxime Battistella, Eduardo Calonje, Andreas Von Deimling, Thibault Kervarrec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pierre SohierDepartment of Pathology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, AP-HP, Centre-Université Paris Cité, Paris, France.ORCID https://orcid.org/0000-0002-2341-6848
Nicolas MacagnoCaraderm Network, Lille, France.ORCID https://orcid.org/0000-0002-9882-2162
Anne TalletPlatform of Somatic Tumor Molecular Genetics, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France.ORCID https://orcid.org/0000-0002-2601-2443
Coralie MoussetDepartment of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France.ORCID https://orcid.org/0000-0002-5787-0264
Maxime BattistellaCaraderm Network, Lille, France.ORCID https://orcid.org/0000-0002-7053-7431
Eduardo CalonjeDepartment of Dermatopathology, St John's Institute of Dermatology, St Thomas's Hospital, London, UK.ORCID https://orcid.org/0000-0001-7475-6423
Andreas Von DeimlingDepartment of Neuropathology, and CCU Neuropathology, University Hospital Heidelberg, DKFZ, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-5863-540X
Thibault KervarrecBiologie des infections à polyomavirus Team, UMR INRA ISP 1282, Université de Tours, Tours, France.ORCID https://orcid.org/0000-0002-2201-6914

Funding

illumina grant
6 · The paper itself

Abstract

aimsDigital papillary adenocarcinoma (DPA) is a rare sweat gland carcinoma arising on acral sites. The main differential diagnosis included tubular adenoma, hidradenoma, poroid hidradenoma, and mixed tumours, distinction between DPA and these mimickers being crucial for therapeutic management. Recently, HPV42 was identified as the main oncogenic driver of most DPA. Controversially, a few sweat gland tumour cases diagnosed as "DPA" but lacking the HPV42 genome and harbouring instead a BRAF METHODS AND

resultsTwelve DPA, 11 tubular adenomas, 12 hidradenomas, 8 apocrine and 6 eccrine mixed tumours, 7 poromas and 6 adnexal sweat gland carcinoma not otherwise specified (NOS) were submitted for DNA methylation profiling. The results of this analysis show that most of these tumour types formed their own unique cluster, setting them apart from the others. In particular, DPA cases clustered together and were distinct from other tumour entities including tubular adenomas.

conclusionsOur data support the distinction between DPA and tubular adenomas as two unique entities and further confirm DNA methylation profiling as a relevant tool for tumour classification.

Indexed as

Adenocarcinoma, PapillaryDNA MethylationSweat Gland NeoplasmsAdultAgedAged, 80 and overDiagnosis, DifferentialFemaleHumansMaleMiddle Aged

Identifiers

PMID40494812
PMCPMC12445876

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.