Evidence map›Paper›PMID 40494582›Full record

ArticleJournal of stroke2025

Aldehyde Dehydrogenase 2 Gene Mutation May Reduce the Risk of Rupture of Intracranial Aneurysm in Chinese Han Population.

Xiheng Chen, Siming Gui, Dachao Wei, Dingwei Deng, Yudi Tang, Jian Lv, Wei You, Jia Jiang, Jun Lin, Huijian Ge and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiheng ChenDepartment of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Siming GuiDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Dachao WeiDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Dingwei DengDepartment of Interventional Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yudi TangDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jian LvDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Wei YouDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jia JiangDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Jun LinDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Huijian GeDepartment of Neurosurgery, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.
Peng LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.
Yuhua JiangDepartment of Neurosurgery, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.
Lixin MaDepartment of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yunci WangDepartment of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Ming LvDepartment of Neurosurgery, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.
Youxiang LiDepartment of Neurosurgery, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China.

Funding

Beijing Municipal Science and Technology, "Jiebang Guashuai" (Open bidding for selecting the best candidates) Project Z231100004823009National Natural Science Foundation of China 82171289
6 · The paper itself

Abstract

background and purposeRuptured intracranial aneurysms (RIA) are associated with a mortality rate of up to 40% in the Chinese population, highlighting the critical need for targeted treatment interventions for at-risk individuals. Although the impact of aldehyde dehydrogenase 2 (ALDH2) gene mutations on susceptibility to intracranial aneurysms (IA) is well documented, the potential connection between ALDH2 rs671 single-nucleotide polymorphism (SNP) and RIA remains unexplored. Given the increased prevalence of ALDH2 gene mutations among Chinese Han individuals, it is clinically relevant to investigate the link between ALDH2 rs671 SNP and IA rupture.

methodsA prospective study was conducted on 546 patients diagnosed with IA to investigate the association between ALDH2 rs671 SNP and the risk of IA rupture.

resultsThe ALDH2 rs671 SNP (ALDH2*2) was significantly more prevalent in patients with unruptured IA (UIA) than in those with RIA (32.56% vs. 18.58%, P=0.004). Multivariate logistic regression analysis revealed that people with the ALDH2 mutation (ALDH2*1/*2 and ALDH2*2/*2 gene type) had a significantly reduced odds ratio (OR=0.49; 95% confidence level [CI] 0.27-0.88; P=0.018) for RIAs. Age-specific subgroup analysis indicated that the ALDH2 mutation provided a stronger protective effect in individuals aged 60 years and above with IA compared to those under 60 years old (OR=0.38 vs. OR=0.52, both P<0.05).

conclusionThe incidence of RIA was significantly higher in individuals with a normal ALDH2 gene (ALDH2*1/*1) than in those with an ALDH2 rs671 SNP (ALDH2*1/*2 or ALDH2*2/*2). ALDH2 rs671 SNP may serve as a protective factor against RIA in the Chinese Han population.

Indexed as

Aldehyde dehydrogenase 2Intracranial aneurysmIntracranial hemorrhageSingle-nucleotide polymorphism

Identifiers

PMID40494582
PMCPMC12152455

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.