Evidence map›Paper›PMID 40494512›Full record

ArticleBiochemistry2025

Isoleucine Binding and Regulation of

Mi-Kyung Yun, Chitra Subramanian, Karen Miller, Pamela Jackson, Christopher D Radka, Charles O Rock

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. ModulatingSynthetic and systems biotechnology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mi-Kyung YunDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.ORCID 0000-0003-1213-5714
Chitra SubramanianDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.ORCID 0000-0003-1101-5307
Karen MillerDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
Pamela JacksonDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
Christopher D RadkaDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.ORCID 0000-0002-6037-7710
Charles O RockDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
REGULATION OF LIPID METABOLISM IN E COLIR01GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 1985 to 2022
$9.2M
REGULATION OF LIPID METABOLISM IN BACTERIAR37GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 2001 to 2010
$5.7M
Bacterial anti-inflammatory lipid mediatorsR00AI166116 · NIAID · UNIVERSITY OF KENTUCKY · PI RADKA, CHRISTOPHER DAVID · 2023 to 2025
$733k
Bacterial anti-inflammatory lipid mediatorsK99AI166116 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RADKA, CHRISTOPHER DAVID · 2022 to 2023
$147k
NCI NIH HHS P30 CA021765NIAID NIH HHS K99 AI166116NIAID NIH HHS R00 AI166116NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P30 GM133893NIGMS NIH HHS P30 GM138395NIGMS NIH HHS R01 GM034496NIGMS NIH HHS R37 GM034496
6 · The paper itself

Abstract

In

Indexed as

Bacterial ProteinsEscherichia coliEscherichia coli ProteinsIsoleucineStaphylococcus aureusThreonine DehydrataseAllosteric RegulationBinding SitesCatalytic DomainCrystallography, X-RayModels, MolecularProtein BindingBacterial ProteinsEscherichia coli ProteinsIsoleucineThreonine Dehydratase

Identifiers

PMID40494512
PMCPMC12224302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.