Evidence map›Paper›PMID 40494385›Full record

ArticleBiomarkers in medicine2025

Susceptibility of RUNX1 promoter rs2071029 polymorphism to adjuvant chemotherapy-induced neutropenia in CRC.

Xikai Luo, Hao Wang, Zhe Huang, Zhuocheng Lin, Chunpeng Li, Qiwen Wang, Yisheng Wei

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Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Xikai LuoDepartment of Anorectal Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Hao WangDepartment of Anorectal Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Zhe HuangDepartment of Anorectal Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Zhuocheng LinDepartment of Anorectal Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Chunpeng LiDepartment of Anorectal Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.
Qiwen WangDepartment of Gastrointestinal Surgery, Lab of Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Yisheng WeiDepartment of Anorectal Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.ORCID 0000-0002-9916-6910

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the susceptibility of Runt-related transcription factor 1 (RUNX1) promoter polymorphism to adjuvant chemotherapy-induced neutropenia (CIN) of colorectal cancer (CRC).

methodsRUNX1 promoter polymorphisms rs2071029 and rs12626613 were genotyped by SnaPshot genotyping and Sanger sequencing. The association of rs2071029 and CIN in 204 CRC patients was analyzed using chi-square test and multivariate logistic regression model. The impact of rs2071029 polymorphism on RUNX1 promoter activity was analyzed by luciferase assay.

resultsRs2071029 and rs12626613 loci were in strong linkage disequilibrium (D ' = 0.957. r

conclusionRUNX1 promoter rs2071029 polymorphism could be useful as an independent biomarker for CIN in CRC.

Indexed as

Colorectal NeoplasmsCore Binding Factor Alpha 2 SubunitGenetic Predisposition to DiseaseNeutropeniaPolymorphism, Single NucleotidePromoter Regions, GeneticAgedChemotherapy, AdjuvantFemaleHumansMaleMiddle AgedCore Binding Factor Alpha 2 SubunitRUNX1 protein, humanchemotherapyColorectal cancerneutropeniaRUNX1single nucleotide polymorphism

Identifiers

PMID40494385
PMCPMC12184163

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