Evidence map›Paper›PMID 40494348›Full record

ArticleCell host & microbe2025

Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism.

Evelyn A Kurt-Jones, Sunita Gulati, Michael King, Rosane B de Oliveira, Peter A Rice, Bo Zheng, Jutamas Shaughnessy, Jennifer L Edwards, Paul J Hertzog, Sanjay Ram and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Evelyn A Kurt-JonesDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Sunita GulatiDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Michael KingDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Rosane B de OliveiraDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Peter A RiceDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Bo ZhengDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jutamas ShaughnessyDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jennifer L EdwardsDepartment of Pediatrics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.
Paul J HertzogCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia; Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia.
Sanjay RamDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Douglas T GolenbockDivision of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: douglas.golenbock@umassmed.edu.

Funding

Neisseria gonorrhoeae exploits host interferon epsilon to establish infection in the female urogenital tractR01AI164727 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GOLENBOCK, DOUGLAS T, RAM, SANJAY · 2021 to 2025
$4.0M
Role of ADAM9 in viral RNA sensing and antiviral innate immunityR21AI174534 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GACK, MICHAELA ULRIKE, KURT-JONES, EVELYN A. · 2023 to 2024
$472k
NIAID NIH HHS R01 AI164727NIAID NIH HHS R21 AI174534
6 · The paper itself

Abstract

The female genital mucosa expresses the hormone-dependent type I interferon (IFN), IFN-epsilon (IFN-ε), which protects against chlamydia and herpes infection. Surprisingly, we found that IFN-ε knockout (Ifnε

Indexed as

GonorrheaInterferonsInterferon Type IN-Acetylneuraminic AcidNeisseria gonorrhoeaeAnimalsAntimicrobial Cationic PeptidesCathelicidinsFemaleImmune EvasionLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutReceptor, Interferon alpha-betaAntimicrobial Cationic PeptidesCathelicidinsInterferonsInterferon Type Ilipid-linked oligosaccharidesLipopolysaccharidesN-Acetylneuraminic AcidReceptor, Interferon alpha-betacathelicidincytidine-5'-monophospho-N-acetylneuraminic acidIFNARinterferon-epsilonlipooligosaccharideNeisseria gonorrhoeaesialylationtype I interferon

Identifiers

PMID40494348
PMCPMC12303037

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.