ArticleCell2025
Microbiota-derived inosine programs protective CD8
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Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
–field-weighted citation impact
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Who cites it
14 citing papers in PubMed.
- Bifidobacteria: biogeography, host adaptation and ecological functions.Nature reviews. Microbiology · 2026Review
- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
- Insights into Microbiota-Vaccine Crosstalk in Humans: Mechanisms, Modulators, and Translational Horizons.Vaccines · 2026Review
- Article
- Immune development in early life.Nature immunology · 2026Review
- Review
- Underexplored maternal microbiomes: immune, metabolic, and microbial pathways shaping pregnancy outcomes.Infection and immunity · 2026Review
- Gut T cell-microbiota crosstalk orchestrates antibacterial immunity and mucosal homeostasis in teleost.Microbiome · 2026Article
- Initial insights into perinatal gut microbiome and early infantile respiratory tract infections.Pediatric research · 2026Article
- Role and Mechanisms of Gut Microbiota in Infectious Diseases: Recent Evidence from Animal Models.Biology · 2026Review
- The neonatal lung microbiome: a dynamic determinant of respiratory health, disease, and novel therapeutics.Frontiers in pediatrics · 2026Review
- The epigenetic-immune-microbiome axis in early life: reprogramming the origins and endotypes of pediatric asthma.Frontiers in immunology · 2026Review
- Microbial metabolite facilitates virus control: inosine and T cells curb early-life influenza infection.Signal transduction and targeted therapy · 2025Article
- The gut microbiome in lung cancer: from pathogenesis to precision therapy.Frontiers in microbiology · 2025Review
Corrections and comments
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Authors and funding
19 authors.
Joseph StevensDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Erica CulbersonDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jeremy KinderDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Infectious Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Alicia RamiriquiDivision of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jerilyn GrayDivision of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Madeline BonfieldDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Tzu-Yu ShaoDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Infectious Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Faris Al GharaibehDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Laura PetersonDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Shelby SteinmeyerDepartment of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA.
Emily M EshlemanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Shikha NegiDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
William ZachariasDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Gloria PryhuberDepartment of Pediatrics, School of Medicine, University of Rochester, Rochester, NY, USA.
Oindrila PaulDivision of Neonatology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shaon SenguptaDivision of Neonatology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Theresa AlenghatDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Sing Sing WayDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Infectious Disease, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hitesh DeshmukhDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: hitesh.deshmukh@cchmc.org.
Funding
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4MBioRepository for INvestigation of Diseases of the Lung (BRINDL) - Phase IIIU01HL148861 · NHLBI · UNIVERSITY OF ROCHESTER · PI GLORIA S PRYHUBER · 2019 to 2026
$9.7MPediatric Center--Gene Expression /Developmental ScienceK12HD028827 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Tina Lee Cheng · 2002 to 2026
$9.6MROLE OF ANGPTL4, AN ANGIOGENIC MEDIATOR, IN ARTHRITISP30AR047363 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI WAGNER, MICHAEL · 2001 to 2015
$9.2MHost integration of commensal and pathogenic bacterial-derived signalsR01DK116868 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Theresa Alenghat · 2018 to 2026
$4.1MCincinnati Center for Excellence in Molecular HematologyP30DK090971 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ZHENG, YI · 2010 to 2015
$4.0MMechanistic evaluation of the role of circadian rhythms in acute lung injury and subsequent recoveryR01HL155934 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI SENGUPTA, SHAON · 2021 to 2025
$2.9MKruppel-like factor-2 CD4+ T cells and intestinal inflammationR01AI172960 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Sing Sing Way · 2023 to 2026
$2.8MEpigenetic regulation of intestinal tuft cellsR01DK137771 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Theresa Alenghat · 2024 to 2026
$2.5MPregnancy induced deacetylation of sialylated glycoproteinsR01AI175431 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Sing Sing Way · 2024 to 2026
$2.3MDefining PRC2 complex epigenomic control in alveolar progenitor cellsR01HL166245 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI William John Zacharias · 2023 to 2026
$2.3MTissue niches for ILC3 development in newborn's lungR01HL155611 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI DESHMUKH, HITESH · 2021 to 2024
$1.9MNHLBI NIH HHS F30 HL165594NHLBI NIH HHS R01 HL155611NHLBI NIH HHS R01 HL155934NHLBI NIH HHS R01 HL156860NHLBI NIH HHS R01 HL166245NHLBI NIH HHS R35 HL177131NHLBI NIH HHS U01 HL148861NIAID NIH HHS R01 AI172960NIAID NIH HHS R01 AI175431NIAMS NIH HHS P30 AR047363NICHD NIH HHS K08 HD084686NICHD NIH HHS K12 HD028827NIDDK NIH HHS K01 DK135647NIDDK NIH HHS P30 DK078392NIDDK NIH HHS P30 DK090971NIDDK NIH HHS R01 DK116868NIDDK NIH HHS R01 DK137771
Abstract
Early-life susceptibility to respiratory viral infections remains a major public health concern, yet the underlying mechanisms are poorly understood. We demonstrate that antibiotic-induced dysbiosis impairs influenza-specific CD8
Indexed as
CD8-Positive T-LymphocytesInfluenza, HumanInosineMicrobiotaAnimalsAnimals, NewbornDysbiosisFemaleGastrointestinal MicrobiomeHepatocyte Nuclear Factor 1-alphaHumansInfant, NewbornLungMaleMiceMice, Inbred C57BLHepatocyte Nuclear Factor 1-alphaInosineimmunologyinfantsinfluenzainosinemicrobiotaT cell responses
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.