Evidence map›Paper›PMID 40494307›Full record

ReviewCurrent biology : CB2025

Cryptococcus.

Sydney L Briner, Tamara L Doering

Abstract readReview
In one paragraph

Review in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Mitochondrial cardiolipin sequestration of caspofungin underliesbioRxiv : the preprint server for biology · 2026
    Article
  6. bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sydney L BrinerDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63108, USA.
Tamara L DoeringDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63108, USA. Electronic address: doering@wustl.edu.

Funding

Natural genomic variants that influence cryptococcal pathogenicityR01AI146320 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2020 to 2024
$3.0M
Solving the puzzle of beta-1,6-glucan in the cryptococcal cell wallR01AI192892 · NIAID · WASHINGTON UNIVERSITY · PI Tamara L Doering, Tuo Wang · 2025 to 2026
$1.5M
Filling gaps in the cryptococcal wall with glycogen and a novel enzymeR21AI175875 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2023 to 2024
$428k
Leveraging genomic approaches to define sterol transport in Cryptococcus neoformansR21AI178330 · NIAID · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2023 to 2024
$428k
NIAID NIH HHS R01 AI146320NIAID NIH HHS R01 AI192892NIAID NIH HHS R21 AI175875NIAID NIH HHS R21 AI178330
6 · The paper itself

Abstract

Fungal pathogens pose a significant threat to human health that is greatly underrecognized, despite causing several million deaths every year. To put it simply, the fight against these fungi is complicated. At baseline, there is a severe lack of effective and accessible antifungals, especially in regions with limited resources. Exacerbating the situation, many of these pathogens are opportunists that primarily affect immunocompromised individuals, which adds to the challenges of treatment. Another concern is that climate change selects for thermotolerance in environmental fungi, enhancing their ability to thrive at human body temperatures. This may not only intensify the danger of existing pathogens but also lead to the emergence of new ones. To focus attention on the serious and escalating threat of fungal pathogens, the World Health Organization has recently classified them into priority categories, designating Cryptococcus neoformans as "critical priority". In this primer, we will discuss the fundamental biology that makes C. neoformans such a notorious pathogen.

Indexed as

CryptococcosisCryptococcus neoformansAnimalsClimate ChangeHumans

Identifiers

PMID40494307
PMCPMC12435927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.