ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Advanced brain aging, selective vulnerability in gray matter, and cognition in Parkinson's disease.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- A discovery protein panel for brain predicted age discordance using MRI in neurologically healthy individuals.Frontiers in cell and developmental biology · 2026Article
- Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundTo identify the most vulnerable brain regions in gray matter attributable to advanced brain aging and examine the cognitive correlates of advanced brain aging in Parkinson's disease (PD).
methodsOne hundred twenty-five early-stage PD patients with both structural, diffusion MRI and DAT-SPECT data available were included at baseline (year 0) from Parkinson's Progression Markers Initiative, with neuroimaging follow-up at year 1, 2, 4. Annual assessment of cognition was performed in 5 years. The relationships between brain-predicted age difference (PAD), free water (FW) in cortical and subcortical gray matter, and cognition were examined with linear regression and linear mixed-effects model. Cox proportional hazards model was used to investigate the relation between brain PAD and the risk of conversion to mild cognitive impairment (MCI).
resultsOne hundred twenty-five PD patients with a mean (SD) chronological age of 60.99 (9.50) years and 82 (65.6%) were men. Brain PAD followed a non-linear progression pattern over time (P = .028). Brain PAD was differentially associated with FW in cortical and subcortical gray matter, with the most preferentially vulnerable regions identified as temporal cortex, striatum, hippocampus, and cholinergic basal forebrain. Baseline brain PAD was associated with cognitive deficits and the conversion to MCI during the 5-year follow-up.
conclusionsOur findings suggest that brain PAD offers potential in pinpointing regions most susceptible to accelerated brain aging and identifying patients with Parkinson's disease who are at an increased risk of converting to mild cognitive impairment. .
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