Evidence map›Paper›PMID 40493889›Full record

ArticleThe British journal of radiology2025

An open-source repository-based tool for quality control of imaging protocol compliance: demonstration in a multicentre MRI study.

Sam Keaveney, Damien J McHugh, Mihaela Rata, Alina Dragan, Jessica M Winfield, Simon J Doran, Matthew D Blackledge, Erica Scurr, Dow-Mu Koh, Michael Berks and 22 more

Abstract readMulticenter Study
In one paragraph

Article in The British journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Precision medicine in myeloma demands precision imaging: is whole body MRI the solution?Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Sam KeaveneyMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.ORCID 0000-0001-7715-0750
Damien J McHughChristie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, M20 4BX, United Kingdom.
Mihaela RataMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.
Alina DraganMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.
Jessica M WinfieldMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.
Simon J DoranMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.
Matthew D BlackledgeMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.
Erica ScurrMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.
Dow-Mu KohMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.
Michael BerksQuantitative Biomedical Imaging, Division of Cancer Sciences, University of Manchester, Manchester, M14 4PX, United Kingdom.
Andrew B GillDepartment of Radiology, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
Jonathan R BirchallDepartment of Radiology, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.
James P B O'ConnorDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, SW3 6JB, United Kingdom.
Alexander KingDepartment of Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, United Kingdom.
Winston J RennieDepartment of Radiology, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, United Kingdom.
Suchi GabaDepartment of Radiology, University Hospitals of North Midlands NHS Trust, ST4 6QG, United Kingdom.
Priya SureshDepartment of Radiology, University Hospitals Plymouth NHS Trust, Plymouth, PL6 8DH, United Kingdom.
Paul MalcolmDepartment of Radiology, Norfolk & Norwich University Hospitals NHS Foundation Trust, Norwich, NR4 7UY, United Kingdom.
Amy DavisDepartment of Radiology, Epsom & St Helier University Hospitals NHS Trust, Epsom, KT18 7EG, United Kingdom.
Anjumara NilakDepartment of Radiology, Worcestershire Acute Hospitals NHS Trust, Worcester, WR5 1DD, United Kingdom.
Aarti ShahDepartment of Radiology, Hampshire Hospitals NHS Foundation Trust, Basingstoke, RG24 9NA, United Kingdom.
Sanjay GandhiDepartment of Radiology, North Bristol NHS Trust, Bristol, BS10 5NB, United Kingdom.
Mauro AlbrizioDepartment of Radiology, Nottingham University Hospitals NHS Trust, Nottingham, NG5 1PB, United Kingdom.
Guy PrattDepartment of Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, United Kingdom.
Gordon CookClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, LS2 9NL, United Kingdom.
Andrew HallClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, LS2 9NL, United Kingdom.
Sadie RobertsClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, LS2 9NL, United Kingdom.
Matthew JennerDepartment of Haematology, University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, United Kingdom.
Sarah BrownClinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, LS2 9NL, United Kingdom.
Martin KaiserDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW3 6JB, United Kingdom.
Penny L Hubbard CristinacceQuantitative Biomedical Imaging, Division of Cancer Sciences, University of Manchester, Manchester, M14 4PX, United Kingdom.
Christina MessiouMRI Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, United Kingdom.ORCID 0000-0002-0557-9379

Funding

Biomedical Research CentreCancer Research UKDepartment of Health and Social CareJanssen and CelgeneNational Cancer Imaging Translational Accelerator 28677National Institute for Health and Care ResearchNHS Foundation TrustNIHRRoyal Marsden Cancer CharityThe Institute of Cancer Research, London NIHR203314
6 · The paper itself

Abstract

objectivesClinical translation of advanced MRI techniques can be hindered by the challenges of performing standardized multicentre imaging trials. This work aims to develop and demonstrate an automated tool for monitoring imaging protocol deviations, enabling corrective action to be taken.

methodsA Python-based tool, integrated into the imaging repository XNAT, was developed to compare DICOM series with an agreed imaging protocol, highlighting missing series and parameter deviations. This was demonstrated through retrospective analysis of a prospectively acquired dataset from a ten-site whole-body (WB) MRI study of patients with multiple myeloma. The acquired data were compared to the relevant radiological guidelines and to the site-specific imaging protocols agreed for the study.

resultsThe rate of technical software failure was 0% across 174 examinations from 10 sites. The clinical guidelines were followed in 87.9% of examinations and compliance with the site-specific imaging protocol was greater than 75.0% for all parameters. Common deviations included number of averages for diffusion-weighted imaging (DWI) and repetition time for DWI and Dixon: 85.2%, 81.7%, and 75.1%, respectively. There was a statistically significant correlation between protocol compliance and overall exam radiological image quality.

conclusionsRepository-integrated software is presented for automated monitoring of imaging protocol compliance to support standardization in multicentre studies and clinical translation. ADVANCES IN KNOWLEDGE: This study presents a novel open-source repository-integrated software tool for automatically monitoring compliance with the expected imaging protocol. Standardized acquisition protocols are crucial in multicentre imaging studies and this tool has the potential to enhance research outcomes and support clinical translation.

Indexed as

Guideline AdherenceMagnetic Resonance ImagingMultiple MyelomaSoftwareWhole Body ImagingHumansQuality ControlRetrospective Studiesclinical translationmagnetic resonance imagingmultiple myelomaquality controlsoftwarewhole-body imaging

Identifiers

PMID40493889
PMCPMC12341670

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.