Evidence map›Paper›PMID 40493676›Full record

ArticleThe Journal of physiology2026

Acute intermittent hypercapnic hypoxia augments left ventricular contractility.

Scott F Thrall, Alex M Williams, Philip J Millar, Megan L Lance, Brooke M Shafer, Conan L H Shing, Jordan D Bird, Christopher R West, Glen E Foster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Scott F ThrallCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada.ORCID https://orcid.org/0000-0002-3203-0461
Alex M WilliamsDepartment of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0003-1571-9168
Philip J MillarDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.ORCID https://orcid.org/0000-0002-2177-1061
Megan L LanceCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada.
Brooke M ShaferSleep, Chronobiology, and Health Laboratory, School of Nursing, Oregon Health and Science University, Portland, OR, USA.ORCID https://orcid.org/0009-0004-4059-7849
Conan L H ShingCentre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, QLD, Australia.ORCID https://orcid.org/0000-0001-6883-1298
Jordan D BirdDivision of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.
Christopher R WestDepartment of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0002-0815-4122
Glen E FosterCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada.ORCID https://orcid.org/0000-0003-4110-9574

Funding

Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2020-04010
6 · The paper itself

Abstract

Acute intermittent hypercapnic hypoxia (IHH) evokes persistent increases in vascular sympathetic activity and blood pressure. Whether myocardial contractility is enhanced to contribute to this pressor response is unknown. We hypothesized that IHH would augment left ventricular systolic function. Twenty-four healthy participants (nine females; aged 25 ± 4 years) underwent 40 consecutive 1 min bouts of 40 s of hypercapnic hypoxia (

Indexed as

HypercapniaHypoxiaMyocardial ContractionVentricular Function, LeftAdultBlood PressureFemaleHumansMaleYoung Adultacute intermittent hypoxiablood pressurecardiac contractilitylower‐body negative pressuresympathetic long‐term facilitation

Identifiers

PMID40493676
PMCPMC13481000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.