SynthesisPloS one2025
The relationship between N-terminal pro-brain natriuretic and coronary artery lesions in Kawasaki disease: A meta-analysis.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegarding the value of N-terminal brain natriuretic peptide precursors in evaluating coronary artery lesions (CAL) in Kawasaki disease.
objectiveTo conduct a meta-analysis of relevant literature and explore the value of N-terminal brain natriuretic peptide NT ProBNP in evaluating coronary artery lesions (CAL) in Kawasaki disease.
methodRetrieve publicly published literature on the relationship between serum NT ProBNP concentration and coronary artery disease in Kawasaki disease from CNKI, Wanfang, VIP, China Biomedical Database, Pubmed, Embase, Cochrane Library, Web of Science, and OVID databases, as well as manually search for other resource literature. Use state14 software to evaluate the quality of the included literature, calculate the combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic ratio ratio, and compile a comprehensive subject working characteristic curve (SROC) to calculate the area under the curve (AUC) and 95% confidence interval.
resultA total of 25 articles were included using a random effects model, with a combined sensitivity of 0.80 [95% CI (0.74, 0.85)], specificity of 0.78 [95% CI (0.75, 0.82)], positive likelihood ratio of 3.94 [95% CI (3.32, 4.69)], negative likelihood ratio of 0.23 [95% CI (0.17, 0.30)], and diagnostic ratio of 17.24 [95% CI (12.0,24.77)]. The area under the SROC curve AUC is 0.87 (0.84-0.90). When the predicted value is 1000ng/L, the combined sensitivity is 0.87 [95% CI (0.80,0.92)], and the specificity is 0.78 [95% CI (0.71,0.84)]. Subgroup analysis revealed that the diagnostic value of NT ProBNP for Kawasaki disease complicated with CAL was higher in the over 3 year old group than in the under 3 year old group. NT ProBNP had higher diagnostic value for Chinese population, but its exclusion value was lower than that of Japanese population. The sensitivity and specificity of using chemiluminescence to detect NT-ProBNP were higher than those of enzyme-linked immunosorbent assay.
conclusionNT-ProBNP has high diagnostic value for coronary artery lesions in Kawasaki disease, and has greater diagnostic value for children over 3 years old, and the use of chemiluminescence.It demonstrates superior diagnostic efficacy for the Chinese population and enhanced exclusionary power for the Japanese population.
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