Evidence map›Paper›PMID 40493483›Full record

Observational studyMedicine2025

Development and validation of muscle strength improvement in 24 hours to predict ischemic stroke patients' outcome after endovascular therapy: A retrospective cohort study.

Zile Yan, Mohammad Mofatteh, Thanh N Nguyen, Robert W Regenhardt, Xuehua Zeng, Suzuki Dharmarasu, Jiale Wu, Baoxin Chen, Zhiyi Zeng, Jianfang Gao and 3 more

Abstract readObservational StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zile YanDepartment of Neurology and Advanced National Stroke Center, Foshan Sanshui District People's Hospital, Foshan, Guangdong Province, China.
Mohammad MofattehSchool of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-2458-0447
Thanh N NguyenDepartment of Neurology, Radiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Robert W RegenhardtDepartment of Neurology, Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Xuehua ZengDepartment of Research and Education, Foshan Sanshui District People's Hospital, Foshan, Guangdong Province, China.
Suzuki DharmarasuDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jiale WuSchool of Medicine, Shaoguan University, Shaoguan, Guangdong Province, China.
Baoxin ChenSchool of Humanities and Social Sciences, Macao Polytechnic Institute, Macao, China.
Zhiyi ZengDepartment of Research and Education, Foshan Sanshui District People's Hospital, Foshan, Guangdong Province, China.
Jianfang GaoDepartment of Neurology and Advanced National Stroke Center, Foshan Sanshui District People's Hospital, Foshan, Guangdong Province, China.
Rongshen YangSchool of Medicine, Shaoguan University, Shaoguan, Guangdong Province, China.
Shuiquan YangDepartment of Neurology and Advanced National Stroke Center, Foshan Sanshui District People's Hospital, Foshan, Guangdong Province, China.ORCID 0000-0001-8192-4130
Xuxing LiaoDepartment of Neurosurgery and Advanced National Stroke Center, Foshan Sanshui District People's Hospital, Foshan, Guangdong Province, China.

Funding

Foshan 14th Five-Year Plan Key Discipline Foundation, Guangdong Provincial TCM Bureau Key Discipline Foundation, Foshan Brain Heart Co-therapy Foundation
6 · The paper itself

Abstract

The relationship between muscle strength improvement and ischemic stroke outcome following endovascular therapy (EVT) for emergency treatment of patients has not been well studied. We developed the prognostic value of the change in muscle strength scores on the Medical Research Council (MRC) scale within 24 hours of EVT as a predictor of EVT outcomes. We retrospectively analyzed prospectively collected data from 142 consecutive patients with ischemic stroke who underwent EVT between August 2018 and February 2022 at a comprehensive stroke center. Early muscle strength improvement (EMSI) was defined as 3 levels of muscle strength improvement on the MRC scale or improvement to grade 4 or 5 of lower-limb muscle strength (LLMS) 24 ± 8 h after EVT. A favorable outcome was defined as a 3-months outcome of the modified Rankin scale (mRS) 0% to 2. 84.2% of EMSI patients had a favorable outcome, in comparison to only 21.2% of non-EMSI patients (P < .001). Similarly, 47.1% of patients died at 3-months in the non-EMSI group, while a significantly lower mortality (8.8%) was observed in the EMSI group (P < .001). LLMS 24 hours post-EVT was significantly associated with 90-day outcomes (P < .001). Early muscle strength improvement in the emergency setting may be a useful predictor of a desired functional outcome in patients with large-vessel occlusion stroke following EVT.

Indexed as

Endovascular ProceduresIschemic StrokeMuscle StrengthAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesTime FactorsTreatment Outcomeendovascular therapyischemic strokemodified Rankin scaleMRC scalemuscle strengthpatient outcome

Identifiers

PMID40493483
PMCPMC12151045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.