Evidence map›Paper›PMID 40493436›Full record

Trial reportAmerican journal of respiratory and critical care medicine2025

Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.

Matt S Zinter, Clove S Taylor, Daniela Markovic, Matteo Pellegrini, Kayley Wong, Brunilda Balliu, Kinisha P Gala, Lisa A Asaro, Vinay M Nadkarni, Patrick S McQuillen and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Diabetes Management Strategies in Intensive Care Settings.The Medical clinics of North America · 2026
    Review
  3. Article
  4. Article
  5. Moving from Observation to Explanation: Probing the Biology of Heterogeneity of Treatment Effects.American journal of respiratory and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Matt S ZinterDivision of Critical Care Medicine and.ORCID 0000-0003-3351-3278
Clove S TaylorDivision of Critical Care Medicine, Department of Pediatrics.ORCID 0009-0001-7434-0951
Daniela MarkovicDivision of General Internal Medicine and Health Sciences Research, Department of Medicine.
Matteo PellegriniDepartment of Molecular, Cell, and Developmental Biology, and.
Kayley WongDivision of Critical Care Medicine, Department of Pediatrics.
Brunilda BalliuDepartment of Computational Medicine, University of California, Los Angeles, Los Angeles, California.
Kinisha P GalaDivision of Critical Care Medicine, Department of Pediatrics.
Lisa A AsaroDepartment of Cardiology and.
Vinay M NadkarniDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Patrick S McQuillenDivision of Critical Care Medicine and.
Sitaram S VangalaDivision of General Internal Medicine and Health Sciences Research, Department of Medicine.
Pratik SinhaDivision of Clinical and Translational Research, Department of Anesthesia, Washington University, Saint Louis, Missouri; and.
Michael A MatthayDepartment of Medicine.
Michael S D AgusDivision of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Anil SapruDivision of Critical Care Medicine, Department of Pediatrics.ORCID 0000-0003-1528-8249

Funding

HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCCU01HL107681 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI AGUS, MICHAEL SD, NADKARNI, VINAY M · 2011 to 2016
$9.6M
Precision Medicine in Sepsis with Critical IllnessR35GM142992 · NIGMS · WASHINGTON UNIVERSITY · PI Pratik Sinha · 2021 to 2026
$2.4M
Hepatic ER stress contributes to morbidity and mortality after burn injury.R01GM087285 · NIGMS · SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR · PI BOEHNING, DARREN F, JESCHKE, MARC GERHARD · 2010 to 2018
$1.9M
Coagulation and Fibrinolysis in Pediatric Insulin Titration TrialR01HL114484 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAPRU, ANIL · 2012 to 2015
$1.6M
Pathobiologic Transcriptional Signatures of Pulmonary Complications in Pediatric Hematopoietic Cellular TransplantationK23HL146936 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZINTER, MATTHEW SCOTT · 2020 to 2024
$980k
NHLBI NIH HHS K23 HL146936NHLBI NIH HHS K23HL146936NHLBI NIH HHS R01 HL114484NHLBI NIH HHS U01 HL107681NIGMS NIH HHS R01 GM087285NIGMS NIH HHS R01GM087285NIGMS NIH HHS R35 GM142992
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BurnsGlycemic ControlHypoglycemic AgentsInflammationInsulinAdolescentBlood GlucoseChildChild, PreschoolCritical IllnessCytokinesFemaleHumansMaleBlood GlucoseCytokinesHypoglycemic AgentsInsulincausal mediationcritical care outcomesinflammationtight glycemic controltranscriptomics

Identifiers

PMID40493436
PMCPMC12318495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.