Evidence map›Paper›PMID 40493345›Full record

ArticleMolecular neurobiology2025

Artemether Improves Aβ

Jun Cai, Yuxuan Liu, Li Gong, Shengfeng Deng, Wenhua Zheng, Shuai Li

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun Cai *Innovation Center of Cardiometabolic Diseases, Guangdong Medical University, Dongguan, China.
Yuxuan Liu *Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
Li Gong *Department of Pharmacy, Longhua District People's Hospital of Shenzhen, Shenzhen, China.
Shengfeng DengGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
Wenhua ZhengPharmaceutical Science, Faculty of Health Sciences and Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR, China.
Shuai LiInnovation Center of Cardiometabolic Diseases, Guangdong Medical University, Dongguan, China. lishuai@gdmu.edu.cn.

Funding

The China Postdoctoral Science Foundation 2023M734024The National Natural Science Foundation of China 82201620
6 · The paper itself

Abstract

Alzheimer's disease (AD) represents the most common manifestation of dementia. Cerebrovascular dysfunction constitutes one of the initial events in the pathogenic process of AD. Recently, our research group has reported that artemether, a first-line antimalarial drug approved by the FDA, exhibits a neuroprotective property. Nevertheless, the impact of artemether on cerebrovascular dysfunction, along with its underlying mechanisms, still awaits comprehensive elucidation. This study systematically investigated the neuroprotective effects of artemether against Aβ

Indexed as

AMP-Activated Protein KinasesAmyloid beta-PeptidesArtemetherBlood-Brain BarrierCalcium-Calmodulin-Dependent Protein Kinase KinaseMitochondriaNeuroprotective AgentsPeptide FragmentsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSignal TransductionAnimalsEndothelial CellsHumansMembrane Potential, MitochondrialMiceMice, Inbred C57BLAMP-Activated Protein KinasesAmyloid beta-Peptidesamyloid beta-protein (1-42)ArtemetherCalcium-Calmodulin-Dependent Protein Kinase KinaseNeuroprotective AgentsPeptide FragmentsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReactive Oxygen SpeciesArtemetherAβ1-42CAMKK2/AMPK/PGC1α pathwayMitochondrial dysfunctionTight junction

Identifiers

PMID40493345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.