Evidence map›Paper›PMID 40493321›Full record

ArticleProbiotics and antimicrobial proteins2026

Anti-Inflammatory Effect and Gut Health of Levilactobacillus brevis Strains in Macrophage and Intestinal Cells.

Su-Jin Min, Eun-Soo Lee, Hyun-Joo Yoon, Na-Kyoung Lee, Hyun-Dong Paik

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Su-Jin MinDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea.
Eun-Soo LeeDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea.
Hyun-Joo YoonDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea.
Na-Kyoung LeeDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea.
Hyun-Dong PaikDepartment of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul, 05029, Republic of Korea. hdpaik@konkuk.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the potential of Levilactobacillus brevis strains (20080 and G1) to alleviate intestinal inflammation and support gut health. Chronic inflammatory conditions are often associated with gut microbiota dysbiosis, suggesting a potential role for probiotics in its management. The anti-inflammatory effects of L. brevis strains were assessed in cellular models of systemic and intestinal inflammation using RAW 264.7 macrophages and HT-29 epithelial cells. In lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, L. brevis strains suppressed pro-inflammatory cytokines and nitric oxide (NO) production while enhancing anti-inflammatory responses. Furthermore, the expression levels of prostaglandin E

Indexed as

Anti-Inflammatory AgentsIntestinesLevilactobacillus brevisMacrophagesProbioticsAnimalsCytokinesGastrointestinal MicrobiomeHT29 CellsHumansInflammationLipopolysaccharidesMiceNF-kappa BNitric OxideRAW 264.7 CellsAnti-Inflammatory AgentsCytokinesLipopolysaccharidesNF-kappa BNitric OxideAnti-inflammatoryLevilactobacillus brevisMitogen-activated protein kinaseNuclear factor-κBProbiotics

Identifiers

PMID40493321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.