ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025
A potential novel predictor of 1-year mortality in elderly hip fracture patients-albumin haemoglobin index.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of multidimensional biomarkers of immune, nutritional, inflammatory, and metabolic status with postoperative outcomes in older hip fracture patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Identification of patient subgroups by hierarchical cluster analysis in femoral neck fractures and surgical outcome analysis.Archives of orthopaedic and trauma surgery · 2026Article
- [Predictive value of the pre-injury Barthel index for 1-year postoperative case fatality rate after hip arthroplasty in elderly patients with hip fracture].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Development and internal validation of prediction model for 90-day mortality in older patients with hip fracture using admission blood parameters.BMC geriatrics · 2026Article
- Nutrition-related clinical laboratory indicators in perioperative management of geriatric hip fractures: a narrative review from risk stratification to precision intervention.Frontiers in nutrition · 2026Review
- Establishment and validation of a clinical prediction model for perioperative pneumonia in elderly patients with hip fractures combined with preoperative stroke.Frontiers in medicine · 2026Article
- From risk marker to life-saver: clinical promise of the albumin hemoglobin index in geriatric hip fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
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Abstract
purposeHip fractures in the elderly are associated with high 1-year mortality rates. Identifying reliable prognostic markers is essential for improving outcomes. The albumin haemoglobin index (AHI), previously studied in gastrointestinal surgery, has not been evaluated in hip fracture patients. This study aimed to assess AHI's prognostic significance in predicting 1-year mortality, with additional hazard model analyses at 3 and 6 months, and compared its performance to other preoperative blood parameters.
methodThis retrospective study included 775 patients aged ≥ 65 years who underwent hip fracture surgery from January 2020 to December 2021. Patients underwent a Fracture Liaison Service. Preoperative blood parameters, including haemoglobin (Hb), albumin (Alb), creatinine (Cr), alkaline phosphatase (ALP), alanine aminotransferase (ALT), red cell distribution width (RDW), and RDW/albumin ratio (RAR), were analysed. AHI was calculated as the product of albumin and haemoglobin. Receiver operating characteristic (ROC) curves assessed the prognostic performance of blood predictors for 1-year mortality, while Cox proportional hazards models evaluated the association between preoperative blood parameters and mortality risk at 3, 6, and 12 months postoperatively.
resultsThe 1-year mortality rate was 16.6% (129/775). ROC analysis showed preoperative AHI as a strong predictor of 1-year mortality (AUC: 0.75, 95% CI: 0.71-0.80, p < 0.001), comparable to RAR (AUC: 0.77, 95% CI: 0.73-0.82) and superior to RDW (AUC: 0.72, 95% CI: 0.67-0.77). Cox models confirmed AHI's predictive value for 1-year mortality (adjusted HR: 3.67, 95% CI: 2.44-5.51, p < 0.001), similar to RAR (adjusted HR: 3.94, 95% CI: 2.62-5.90) and higher than RDW (adjusted HR: 2.12, 95% CI: 1.43-3.14). AHI < 3331, RAR > 0.468, and RDW > 14.15% were significant predictors, with consistent trends at 3 and 6 months in hazard models.
conclusionAHI is a potential novel predictor of 1-year mortality in elderly hip fracture patients, with prognostic performance comparable to RAR and superior to RDW. Its integration into preoperative assessments may enhance risk stratification and guide interventions to reduce mortality, offering a simple and accessible biomarker for clinical use. Preoperative albumin haemoglobin index (AHI) demonstrated strong prognostic accuracy for 1-year mortality in elderly hip fracture patients (AUC: 0.75, 95% CI: 0.71-0.80, p < 0.001; adjusted HR: 3.67, 95% CI: 2.44-5.51, p < 0.001), with an optimal cutoff value of < 3331. AHI is a potential novel biomarker for predicting 1-year mortality in this population.
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