Evidence map›Paper›PMID 40493197›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Repurposing a drug to punish carbapenem-resistant

Jennifer M Colquhoun, Carter U Brzezinski, Andrew Ji, Julianna Marotta, Franziska A V Elsen, Robert A Bonomo, Kerrie L May, Stephan A Sieber, Marcin Grabowicz, William M Wuest and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Revisiting the Fight AgainstAntibiotics (Basel, Switzerland) · 2026
    Review
  9. Liganded LolCDE structures reveal a common substrate-LolE interaction guiding bacterial lipoprotein transport.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Antimicrobial Resistance: The Answers.British journal of biomedical science · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer M ColquhounResearch Service, Atlanta VA Medical Center, Decatur, GA 30033.
Carter U BrzezinskiDepartment of Chemistry, Emory University, Atlanta, GA 30322.
Andrew JiResearch Service, Atlanta VA Medical Center, Decatur, GA 30033.ORCID 0009-0000-8049-8520
Julianna MarottaDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-6338-0667
Franziska A V ElsenDepartment of Bioscience, Center for Functional Protein Assemblies, Technical University of Munich, School of Natural Sciences, Garching D-85747, Germany.ORCID 0009-0001-5703-0548
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, OH 44106.
Kerrie L MayDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0002-4302-2440
Stephan A SieberDepartment of Bioscience, Center for Functional Protein Assemblies, Technical University of Munich, School of Natural Sciences, Garching D-85747, Germany.
Marcin GrabowiczDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322.ORCID 0000-0001-8000-2222
William M WuestDepartment of Chemistry, Emory University, Atlanta, GA 30322.ORCID 0000-0002-5198-7744
Philip N RatherResearch Service, Atlanta VA Medical Center, Decatur, GA 30033.ORCID 0000-0001-9674-6250

Funding

Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8M
Atlanta Network for Training In KUH Scientific Research (ATLANTIS)TL1DK136047 · NIDDK · EMORY UNIVERSITY · PI Vivien Andrea Sheehan · 2022 to 2026
$3.0M
Lipoprotein trafficking to the bacterial outer membraneR35GM133509 · NIGMS · EMORY UNIVERSITY · PI GRABOWICZ, MARCIN · 2019 to 2023
$1.9M
Lipoprotein trafficking to the bacterial outer membraneR35GM156739 · NIGMS · EMORY UNIVERSITY · PI Marcin Grabowicz · 2025 to 2026
$875k
BLRD VA I01 BX001725BLRD VA I01 BX001974BLRD VA IK2 BX005911BLRD VA IK6 BX004470HHS | NIH (NIH) AI72219NIAID NIH HHS R01 AI072219NIDDK NIH HHS TL1 DK136047NIGMS NIH HHS R35 GM119426NIGMS NIH HHS R35 GM133509NIGMS NIH HHS R35 GM156739U.S. Department of Veterans Affairs (VA) I01BX001725U.S. Department of Veterans Affairs (VA) IK2BX005911U.S. Department of Veterans Affairs (VA) IK6BX004470
6 · The paper itself

Abstract

The OXA β-lactamases in

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsCarbapenemsDrug RepositioningDrug Resistance, BacterialAcinetobacter Infectionsbeta-LactamasesEscherichia coliHumansMicrobial Sensitivity TestsAnti-Bacterial Agentsbeta-lactamase OXA-23beta-LactamasesCarbapenemsAcinetobacter baumanniiantibiotic resistancedrug repurposingfendilineOXA beta-lactamase

Identifiers

PMID40493197
PMCPMC12184509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.