ArticleProceedings of the National Academy of Sciences of the United States of America2025
A synthetic jasmonate receptor agonist uncouples the growth-defense trade-off in rice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Signaling by a tyrosine-sulfated peptide balances growth and osmotic stress response in rice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A transcription factor TOE3 simultaneously promotes growth and antiviral immunity by disrupting ABA core module in tobacco.Science advances · 2026Article
- Chemical treatment rescues reduced growth of the autoimmune mutant chs3-2D without compromising its immune responses.Plant biology (Stuttgart, Germany) · 2026Article
- Plant strategies against herbivorous insects.Journal of integrative plant biology · 2026Review
- Transcending the jasmonate-mediated growth-defense trade-off: Pathways to unlocking plant potential.Plant communications · 2026Review
- Integrated metabolome and transcriptome profiling demonstrates dynamic regulatory roles of hormones in direct-seeding rice.Frontiers in plant science · 2026Article
- The role of jasmonates in plant root growth and development.Frontiers in plant science · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
Herbivore attack elicits jasmonate (JA) signaling which in turn elicits both anti-herbivore plant defenses and growth inhibitions. The resulting growth-defense trade-offs constrain the utility of JA-based plant defense inducers to enhance endogenous pest resistance. Here, we designed and screened selective JA receptor agonists by synthesizing 6-substituted 1-oxoindanoyl isoleucine (In-Ile) conjugates and their free-acid forms, structural mimics of the bioactive hormone (+)-7-iso-jasmonoyl-L-Ile. These compounds differentially activate JA responses through selective binding of specific COI-JAZ coreceptor complexes. Notably, In-Ile treatments enhanced rice resistance to brown planthopper attack, a destructive rice pest, under both laboratory and field conditions, without compromising rice's growth or yield. Mechanistically, this agonist activates the OsMYB55-mediated lignin biosynthesis defense receptor module [OsCOI1a/2-OsJAZs (3,4,6,7,12)] without activating the growth-suppression receptor module (OsCOI1b-OsJAZs). These findings demonstrate that synthetic JA agonists can provide nuanced manipulations of endogenous plant defenses without yield penalties-a promising biorational strategy for pest control in rice.
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