ArticleProceedings of the National Academy of Sciences of the United States of America2025
Electrical spinal cord stimulation promotes focal sensorimotor activation that accelerates brain-computer interface skill learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Multifunctional material platforms for neural interfaces: active orchestration of dynamic foreign body response across implantation lifetimes.Bioactive materials · 2026Review
- Highly stretchable, hair-compatible multichannel neural interface with time-stable hydrogel for high-fidelity long-term EEG sensing.Science advances · 2026Article
- Spasticity and Abnormal Tone Regulation After Spinal Cord Injury: Mechanisms and the Effects of Neuromodulation.Biomedicines · 2026Review
- Targeting the glial-fibrotic scar microenvironment after spinal cord injury: From integrated protection to systematic regulation of regenerative balance.Journal of orthopaedic translation · 2026Review
- Reopening Motor Learning Windows: Targeted Re-Engagement of Latent Pathways via Non-Invasive Neuromodulation.Life (Basel, Switzerland) · 2026Review
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Authors and funding
7 authors.
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Abstract
Injuries affecting the central nervous system may disrupt neural pathways to muscles causing motor deficits. Yet the brain exhibits sensorimotor rhythms (SMRs) during movement intents, and brain-computer interfaces (BCIs) can decode SMRs to control assistive devices and promote functional recovery. However, noninvasive BCIs suffer from the instability of SMRs, requiring longitudinal training for users to learn proper SMR modulation. Here, we accelerate this skill learning process by applying cervical transcutaneous electrical spinal stimulation (TESS) to inhibit the motor cortex prior to longitudinal upper-limb BCI training. Results support a mechanistic role for cortical inhibition in significantly increasing focality and strength of SMRs leading to accelerated BCI control in healthy subjects and an individual with spinal cord injury. Improvements were observed following only two TESS sessions and were maintained for at least one week in users who could not otherwise achieve control. Our findings provide promising possibilities for advancing BCI-based motor rehabilitation.
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