Evidence map›Paper›PMID 40493159›Full record

ArticleJournal of cancer survivorship : research and practice2025

Partnership and fatherhood outcomes in young men diagnosed with cancer: a nationwide register-based study.

Line Bentsen, Helle Pappot, Kirsten Tryde Macklon, Lone Schmidt, Ditte Vassard

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Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Line BentsenDepartment of Oncology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. Line.Bentsen.01@regionh.dk.
Helle PappotDepartment of Oncology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Kirsten Tryde MacklonFertility Clinic, Department of Gynaecology, Fertility and Childbirth, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Lone SchmidtSection of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Ditte VassardFertility Clinic, Department of Gynaecology, Fertility and Childbirth, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA cancer diagnosis during young adulthood can impact identity, relationships, and family building. While young men with cancer face fertility risks, data on fatherhood and partnership outcomes remain limited. This study aimed to examine the hazard ratios (HRs) for fatherhood and partnership formation in young men diagnosed with cancer compared to age-matched comparisons.

methodsThis nationwide register-based study, based on the DANAC II cohort, included men diagnosed with cancer at 18-39 years (1978-2016) and age-matched male comparisons. Cox regression models estimated HRs of fatherhood and partnership formation, adjusting for time of diagnosis or study entry, immigration status, and pre-diagnosis children.

resultsAmong 16,913 men with cancer and 1,353,040 comparisons, those with cancer had a lower HR of fatherhood (0.88 [95% confidence interval (CI) 0.86-0.91]), the lowest among men with lymphoma, central-nerve system (CNS), and gastrointestinal cancers. Fatherhood probabilities improved over time, with older men showing the greatest gains. Among men who were single at diagnosis or study entry, the HR for partnership formation was similar to the comparison group (1.03 [95% CI 0.99-1.07]), except for those with gastrointestinal or CNS cancers.

conclusionsFatherhood HRs were generally lower than in comparisons, varying by cancer group, age, and diagnosis period. However, single men diagnosed with cancer typically formed partnerships similar to the comparisons. IMPLICATIONS FOR CANCER SURVIVORS: The lower probability of fatherhood highlights the need for and importance of oncofertility counseling, timely fertility preservation referrals, and follow-up care tailored to cancer groups and age at diagnosis.

Indexed as

CancerEpidemiologyFatherhoodInfertilityYoung adults

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.