ArticleJournal of assisted reproduction and genetics2025
A novel small droplets freezing method for human sperm cryopreservation: maximizing utilization of limited samples.
Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
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6 authors.
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Abstract
purposeThe study aims to evaluate and compare sperm progressive motility before and after cryopreservation using the conventional slow freezing technique versus a novel small droplets freezing method. This research seeks to determine the optimal freezing technique, particularly for preserving unique and irreplaceable sperm samples.
methodsSeventy-five sperm samples were divided and cryopreserved using two techniques: (1) the classic slow freezing method and (2) the small droplets freezing method. After thawing, sperm progressive motility was assessed and compared between the two methods.
resultsNo significant difference in sperm progressive motility was observed between the two techniques. The mean post-thaw progressive motility was 22.9% for the classical method and 23.64% for the small droplets method (p = 0.74), indicating comparable outcomes.
conclusionCryopreservation in small droplets maintains sperm progressive motility similarly to conventional slow freezing. This technique allows for more efficient utilization of limited sperm samples, making it particularly valuable for posthumous sperm retrieval, fertility preservation in oncological patients, and cases where sperm availability is extremely limited.
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