Evidence map›Paper›PMID 40493145›Full record

ArticleAIDS and behavior2025

Development and Evaluation of Decision Partner: A Decision Aid for HIV Remission Clinical Trial Participation.

Rebecca R Moultrie, Gail Henderson, Sarah Nelson Potter, Emily Cheves, Kristine J Kuczynski, Dean Jackman, Stuart Rennie, Cynthia Gay, Chelsea Gieck, Yujiemi Chisholm and 1 more

Abstract read
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In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rebecca R MoultrieCenter for Communication and Engagement Research, Center for Communication Science, RTI International, 3040 E. Cornwallis Road, P.O. Box 12194, 27709, Research Triangle Park, NC, USA. rmoultrie@rti.org.ORCID http://orcid.org/0000-0003-2102-2287
Gail HendersonSchool of Medicine, Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-4968-7064
Sarah Nelson PotterGenOmics, Center of Analytics, RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-8640-8992
Emily ChevesGenOmics, Center of Analytics, RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0001-8801-0411
Kristine J KuczynskiSchool of Medicine, Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-5936-9019
Dean JackmanCenter for Technology, Center for Data Modernization Solutions, RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-2219-9968
Stuart RennieSchool of Medicine, Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-3844-972X
Cynthia GayDivision of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-3620-3059
Chelsea GieckCenter for Systems Engineering, RTI International, Research Triangle Park, NC, USA.
Yujiemi ChisholmCenter for Systems Engineering, RTI International, Research Triangle Park, NC, USA.
Holly L PeayGenOmics, Center of Analytics, RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-3053-7453

Funding

Decision Support for Early-Phase HIV Remission TrialsR34MH123328 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HENDERSON, GAIL E, PEAY, HOLLY LANDRUM · 2021 to 2022
$760k
NIH HHS R34MH123328
6 · The paper itself

Abstract

HIV remission (or cure) clinical trials require potential participants to understand trial-related risks, approaches to minimize risks, potential benefits, procedures, and participation alternatives to make an informed decision. Decision aids (DAs) support preference-sensitive decisions. We report on the development and evaluation of a DA called Decision Partner, designed to support informed consent. We used an iterative, mixed-methods approach to develop and test Decision Partner. We conducted research and engagement activities among people living with HIV (PLWHIV), advocates, researchers, trialists, and clinicians which resulted in a product reflective of information required for informed choice. Among 20 PLWHIV, 90% rated that Decision Partner would be useful for decision-making. Decision conflict significantly decreased after using Decision Partner (37.3 to 16.8, p =.007) and knowledge significantly increased from pre to-post(z = -3.11, p <.01). Our findings indicated that Decision Partner holds promise to augment the informed consent process, in HIV remission trials.

Indexed as

Clinical Trials as TopicDecision MakingDecision Support TechniquesHIV InfectionsInformed ConsentPatient ParticipationAdultFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedRemission InductionDecision aidDecision supportHIV remission clinical trialsInformed consent

Identifiers

PMID40493145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.