ArticleEpilepsia2025
Seizure freedom after surgical resection of diffusion-weighted magnetic resonance imaging abnormalities.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Open diffusion magnetic resonance imaging and connectivity data for epilepsy and surgery: The IDEAS II release.Epilepsia · 2026Article
- Multimodal integration of magnetic resonance imaging and intracranial electroencephalographic abnormalities in temporal lobe epilepsy surgery.Epilepsia · 2026Article
- Article
- Combined impact of gray and superficial white matter abnormalities: Implications for epilepsy surgery.Epilepsia · 2025Article
- Seizure freedom after surgical resection of diffusion-weighted magnetic resonance imaging abnormalities.Epilepsia · 2025Article
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13 authors.
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Abstract
objectiveSuccessful epilepsy surgery requires accurate localization and removal of the epileptogenic zone. Neuroimaging helps detect structural brain abnormalities to guide surgery, but current clinical practice does not use diffusion-weighted magnetic resonance imaging (dwMRI). However, previous work has shown that diffusion abnormalities are present in epilepsy and may relate to the epileptogenic zone. Here, we investigate whether surgical resection of diffusion abnormalities relates to postoperative seizure freedom.
methodsWe investigated the association between surgical resection of diffusion abnormalities and postoperative seizure freedom in 200 individuals with drug-resistant focal epilepsy using dwMRI. A cohort of 97 healthy controls provided a normative baseline for dwMRI metrics, allowing calculation of voxelwise z-scores to identify abnormal clusters in both gray and white matter.
resultsSurgical resections overlapping with the largest abnormal cluster significantly correlated with sustained seizure freedom at 12 months (83% vs. 55%; SIGNIFICANCE: Our results suggest that abnormal clusters, identified using dwMRI, are integral to the epileptogenic network, and even a partial removal of such an abnormal cluster is sufficient to achieve seizure freedom. This study highlights the potential of incorporating dwMRI into presurgical planning to improve outcomes in focal epilepsy by reliably identifying and targeting diffusion abnormalities.
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