ArticleJournal of bacteriology2025
The DigH glycosyl hydrolase is conditionally required for daughter cell separation in
Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Tail-specific protease (Tsp)-mediated envelope remodeling and beta-lactam tolerance inMicrobiology spectrum · 2026Article
- The lytic transglycosylase MltA participates in turnover of septal peptidoglycan inbioRxiv : the preprint server for biology · 2026Article
- Phage-antibiotic synergy restores β-lactam efficacy in MDR Klebsiella quasipneumoniae biofilms and suppresses resistance.Journal of biomedical science · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The peptidoglycan (PG) cell wall is a mesh-like layer that shapes bacteria and protects against osmotically induced lysis. PG is composed of glycan strands and peptide chains that link together to form a continuous layer that surrounds the cell. PG hydrolases are required for cell wall maturation, and many are employed during cell separation. During cell division, amidases remove peptides from the glycan backbone, and the resulting denuded glycans (dnGs) are degraded by lytic transglycosylases (LTs). The gram-negative bacterium IMPORTANCE: Most bacteria are surrounded by an essential polymer known as the peptidoglycan cell wall. During cell division, a transient form of peptidoglycan is generated between the developing daughter cells that must be cleaved so that cells can separate. Here, we show that the DigH hydrolase is conditionally required for cell separation when this transient cell wall structure accumulates in the gram-negative bacterium
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Registered trials
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