Evidence map›Paper›PMID 40492711›Full record

ArticleMicrobiology spectrum2025

Phage steering in the presence of a competing bacterial pathogen.

Sean Czerwinski, James Gurney

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sean CzerwinskiSchool of Biology, Georgia State University, Atlanta, Georgia, USA.ORCID 0009-0000-5731-5941
James GurneySchool of Biology, Georgia State University, Atlanta, Georgia, USA.ORCID 0000-0002-8364-3380

Funding

Cystic Fibrosis Research GURNEY20F0-CIGeorgia State University MBD program
6 · The paper itself

Abstract

The rise of antibiotic-resistant bacteria has necessitated the development of alternative therapeutic strategies, such as bacteriophage therapy, where viruses infect bacteria, reducing bacterial burden. However, rapid bacterial resistance to phage treatment remains a critical challenge, potentially leading to failure. Phage steering, which leverages the evolutionary dynamics between phage and bacteria, offers a novel solution by driving bacteria to evolve away from virulence factors or resistance mechanisms. In this study, we examined whether phage steering using bacteriophage Luz19 could function in the presence of a competing pathogen,

Indexed as

BacteriophagesPseudomonas aeruginosaPseudomonas PhagesStaphylococcus aureusFimbriae, BacterialPhage TherapyVirulence FactorsVirulence Factorsbacteriophage evolutionbacteriophagesbacteriophage therapysteeringvirulence

Identifiers

PMID40492711
PMCPMC12211013

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.