The Junctional Epithelium Attachment Is Regulated by Wnt Signaling.

F Aellos, P L Cuevas, K G Harder, J A Grauer, A Ramos, B Liu, J A Helms

Abstract read

In one paragraph

Article in Journal of dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

F AellosDepartment of Surgery, Stanford School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8854-4253

P L CuevasDepartment of Surgery, Stanford School of Medicine, Stanford University, Stanford, CA, USA.

K G HarderMax Rady College of Medicine, University of Manitoba, Winnipeg, Canada.

J A GrauerDr. Gerald Niznick College of Dentistry, University of Manitoba, Winnipeg, Canada.

A RamosDepartment of Surgery, Stanford School of Medicine, Stanford University, Stanford, CA, USA.

B LiuDepartment of Surgery, Stanford School of Medicine, Stanford University, Stanford, CA, USA.

J A HelmsDepartment of Surgery, Stanford School of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0463-396X

Funding

Molecular mechanisms mediating the soft tissue attachment to teethR01DE031270 · NIDCR · STANFORD UNIVERSITY · PI Jill A Helms · 2023 to 2026

$2.9M

NIDCR NIH HHS R01 DE031270

6 · The paper itself

Abstract

The molecular mechanisms mediating barrier functions of the junctional epithelium (JE) are incompletely understood. The aim of this study was to gain mechanistic insights into how reduced Wnt/β-catenin signaling affects the metabolism, turnover, and attachment of JE cells to the tooth surface. A membrane-permeable selective inhibitor of the Wntless protein, C59, was topically delivered to the JE. Wnt pathway suppression was verified by using

Indexed as

Epithelial AttachmentWnt Signaling PathwayAlveolar Bone LossAnimalsApoptosisMiceapoptosisbeta catenincell proliferationepithelial cellshemidesmosomesperiodontitis

Identifiers

PMID40492573

DOI10.1177/00220345251336168

PMCPMC13044411

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.