Evidence map›Paper›PMID 40492532›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A MXene-Based Nanothermal Knife Inhibits Aggresome-Mediated Persister Formation for Preventing Dental Caries.

Yinyin Zhang, Leilei Yang, Jing Jiao, Wenshuai Li, Sen Lin, Xianlong Zong, Haoyang Qin, Danfeng Liu, Rui Li

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yinyin ZhangDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.
Leilei YangDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.
Jing JiaoDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.
Wenshuai LiDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.
Sen LinDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.
Xianlong ZongDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.
Haoyang QinDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.
Danfeng LiuDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.
Rui LiDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 45000, China.ORCID https://orcid.org/0000-0003-3142-0633

Funding

Henan Medical Science and technology research project SBGJ202002073Henan Provincial Medical Science and Technology Tackling Program LHGJ20220383National Natural Science Foundation of China 82303351National Natural Science Foundation of China 82401090Nature Science Foundation of Henan province 222300420569Scientific Research and Innovation Team of the First Affiliated Hospital of Zhengzhou University QNCXTD2023021Young and Middle-aged Health Science and Technology Innovation Leading Talents in Henan Province YXKC2021014
6 · The paper itself

Abstract

Early childhood caries (ECC) is one of the most common chronic diseases among children globally, affecting the health and quality of life of children. Despite various treatments, cariogenic bacteria persist, resulting in a pessimistic outlook for the prevention and treatment of ECC. A notable presence of persister cells is found within the cariogenic bacterial population, with their dormancy enabling them to evade antiseptics. Mechanistically, the downregulation of heat shock proteins (HSPs) leads to protein aggresome formation, converting active cariogenic bacteria into persisters, which confers dual defensive barriers through metabolic inertness and concomitant reduction of membrane permeability, rendering conventional antimicrobials ineffective. Given these findings, Ti

Indexed as

Dental CariesNanostructuresPhotothermal TherapyTitaniumAnimalsAnti-Bacterial AgentsBiofilmsHumansMiceNitritesStreptococcus mutansTransition ElementsAnti-Bacterial AgentsMXeneNitritesTitaniumtitanium carbideTransition Elementsearly childhood cariesheat shock proteinmultispecies biofilmspersisterphotothermal therapy

Identifiers

PMID40492532
PMCPMC12412528

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.