ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Perceptual discrimination of complex objects: Apolipoprotein E e4 gene-dose effects in mid-life.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Perceptual discrimination of complex objects: Apolipoprotein E e4 gene-dose effects in mid-life.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
introductionComplex perceptual discrimination is supported by tau-vulnerable regions of the medial temporal lobe (MTL); notably the perirhinal cortex. This research tests whether there is a gene-dose effect of apolipoprotein E (APOE) e4 on perceptual discrimination in mid-life.
methodsThree hundred and thirteen adults (45-65 years; grouped by APOE e4 gene-dose (142 APOE33, 135 APOE34, 36 APOE44)) completed a Greebles "odd-one-out" task.
resultsAPOE44 carriers were significantly less accurate in their perceptual judgments than APOE33 and APOE34 individuals. There was a significant Age x APOE e4 gene-dose interaction in response speed, with the slope of age-related slowing increasing stepwise with the number of e4 alleles carried. Estimates suggest high-risk individuals are quicker than the APOE33 control group until age 54, but slower thereafter. DISCUSSION: Perceptual disadvantages specific to APOE44 individuals suggest this high-risk group show compromised MTL function by mid-life, potentially through accelerated tau-aggregation. Task performance in APOE34 carriers is relatively preserved in mid-life. HIGHLIGHTS: APOE44 carriers show impaired perceptual discrimination in mid-age. APOE34 carriers show preserved perceptual discrimination in mid-age. Age-related slowing of perceptual judgments increases with APOE e4 gene-dose. Perceptual discrimination tasks may be a valuable early marker of AD risk.
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