ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
ROS-Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling.
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Bionic intelligent responsive barbed microneedles synergistically remodel the microenvironment for the treatment of refractory pigmentation disorders (melasma).Materials today. Bio · 2026Article
- Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The nicotinamide phosphoribosyltransferase inhibitor FK866 restricts influenza A virus replication by perturbing viral polymerase activity.Journal of virology · 2026Article
- Research Progress on Natural Polysaccharide Hydrogels in the Diagnosis and Treatment of Colorectal Cancer.Gels (Basel, Switzerland) · 2026Review
- Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review).Oncology reports · 2026Review
- Mucoadhesive oral nanovaccine delivery system with immunomodulatory capacity for synergistic colorectal cancer therapy.Materials today. Bio · 2026Article
- Mitophagy-driven multidimensional regulation of tumor immune evasion and context-dependent therapeutic strategies.Journal of translational medicine · 2026Review
- The role of NADFrontiers in oncology · 2026Review
- Bio-Polymers Based Functionalized Hydrogel Carriers for Targeted Oncology Therapies: Current Progress and Future Perspectives.International journal of nanomedicine · 2026Review
- Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms.MedComm · 2025Review
- In situ forming hydrogels for colorectal cancer therapy.Materials today. Bio · 2025Review
- ROS-Responsive Hydrogel for Localized Delivery of Nampt and Stat3 Inhibitors Exhibits Synergistic Antitumor Effects in Colorectal Cancer Through Ferroptosis Induction and Immune Microenvironment Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Chenyang YeDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.ORCID https://orcid.org/0000-0002-3695-6309
Mi MiDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Saimeng ShiDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Lina QiDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Shanshan WengDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Lu WangCenter for Plastic & Reconstructive Surgery, Department of Plastic &Reconstructive, Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 310014, P. R. China.
Yier LuDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Chao ChenDepartment of Colorectal Surgery and Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, Key Laboratory of Molecular Biology in Medical Sciences, China National Ministry of Education; Zhejiang Province, China), The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310058, China.
Yinuo TanDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Mengyuan YangDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Cheng GuoZhejiang Provincial Clinical Research Center for CANCER, Hangzhou, Zhejiang, 310009, China.
Rui BaiDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Xuefeng FangDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Ji WangCenter for Plastic & Reconstructive Surgery, Department of Plastic &Reconstructive, Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 310014, P. R. China.ORCID https://orcid.org/0000-0002-7771-5819
Ying YuanDepartment of Medical Oncology, Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, School of Medicine, Ministry of Education, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Funding
Basic Scientific Research Funds of Department of Education of Zhejiang Province KYQN202109Key Research and Development Program of Zhejiang Province 2021C03125National Natural Science Foundation of China 82102708Start-up funding of Zhejiang Provincial People's Hospital ZRY2021A001
Abstract
Targeting Nampt to modulate NAD
Indexed as
Antineoplastic AgentsColorectal NeoplasmsCytokinesFerroptosisHydrogelsNicotinamide PhosphoribosyltransferaseReactive Oxygen SpeciesSTAT3 Transcription FactorTumor MicroenvironmentAcrylamidesAnimalsCell Line, TumorDrug SynergismHumansMicePiperidinesAcrylamidesAntineoplastic AgentsCytokinesHydrogelsN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanPiperidinesReactive Oxygen SpeciesSTAT3 protein, humanSTAT3 Transcription Factorcolorectal cancerferroptosisFK866reactive oxygen species (ROS)‐responsive hydrogeltumor immune microenvironment
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.