Evidence map›Paper›PMID 40492492›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Convertible ROS Nanocatalyst/Eliminator for Enhancing Tumor Radio-Immunotherapy and Relieving Radiation Enteritis.

Mengmeng Zhang, Xinyu Zhang, Chenyu Wang, Mengyao Mu, Ke Ren, Nengyi Ni, Li Xian Yip, Kai Guo, Xiaoyu Hu, Feifei Teng and 3 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mengmeng ZhangDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
Xinyu ZhangMedical Science and Technology Innovation Center, Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Chenyu WangMedical Science and Technology Innovation Center, Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Mengyao MuMedical Science and Technology Innovation Center, Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Ke RenMedical Science and Technology Innovation Center, Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Nengyi NiDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
Li Xian YipDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.
Kai GuoMedical Science and Technology Innovation Center, Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
Xiaoyu HuDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
Feifei TengDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
David Tai LeongDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.
Qing FanDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
Xiao SunDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.ORCID https://orcid.org/0000-0001-6506-1574

Funding

China Postdoctoral Science Foundation 2024M761874Collaborative Academic Innovation Project of Shandong Cancer Hospital TS002Collaborative Academic Innovation Project of Shandong Cancer Hospital TS009National Natural Science Foundation of China 82372031Natural Science Foundation of Shandong 2022HWYQ-079Natural Science Foundation of Shandong ZR2024MH085Natural Science Foundation of Shandong ZR2024QB135Natural Science Foundation of Shandong ZR2024QH013Youth Innovation Science and Technology Program of Shandong Provincial Universities 2023KJ345
6 · The paper itself

Abstract

Radiation-induced damage to normal tissue seriously disrupts the execution of radiotherapy (RT) and therefore attenuates its efficacy. Exploring new strategies to enhance the efficacy and reduce toxicity of RT has great clinical importance. Here, a PD-L1 affibody (Z

Indexed as

EnteritisImmunotherapyNeoplasmsRadiation InjuriesReactive Oxygen SpeciesAnimalsCell Line, TumorHumansMiceRadiotherapyReactive Oxygen Speciesefficacy enhancementJanus nanoarchitecturesradiation enteritisradiotherapytoxicity reduction

Identifiers

PMID40492492
PMCPMC12412606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.