Evidence map›Paper›PMID 40492450›Full record

ArticleChemphyschem : a European journal of chemical physics and physical chemistry2025

Fluorescence Lifetime Imaging Microscopy Analysis of Isolated Melanosomes.

Mykyta Kizilov, Sujeong Jung, Vsevolod Cheburkanov, Vladislav V Yakovlev

Abstract read
In one paragraph

Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Label-Free Optical Investigation of Structural and Thermal Changes in Fat and Lean Beef under Frozen Storage.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mykyta KizilovDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Sujeong JungDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Vsevolod CheburkanovDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Vladislav V YakovlevDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.ORCID 0000-0002-4557-1013

Funding

Brillouin Microscope for Biomedical ResearchR01GM127696 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI YAKOVLEV, VLADISLAV V. · 2018 to 2021
$1.1M
Molecular and cellular imaging of bone biopsies using AI augmented deep UV Raman microscopyR21CA269099 · NCI · TEXAS ENGINEERING EXPERIMENT STATION · PI BEREZIN, MIKHAIL Y., YAKOVLEV, VLADISLAV V. · 2022 to 2024
$577k
Sensing local nano-environment with coherent Raman microspectroscopyR21GM142107 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI YAKOVLEV, VLADISLAV V. · 2021 to 2022
$399k
Air Force Office of Scientific Research FA9550-20-1-0366 and FA9550-23-1-0599National Institutes of Health (US) R01GM127696National Institutes of Health (US) R21CA26909National Institutes of Health (US) R21GM142107NCI NIH HHS R21 CA269099NIGMS NIH HHS R01 GM127696NIGMS NIH HHS R21 GM142107U.S. Food and Drug Administration 80ARC023CA002E
6 · The paper itself

Abstract

Melanosomes are organelles found in a wide variety of tissues throughout the animal kingdom. They contain a variety of biological molecules, but the dominant constituent is the pigment melanin, and many functions ascribed to melanosomes, such as photoprotection, are uniquely enabled by the chemical properties and structures of the melanins they contain. In this report, fluorescence lifetime imaging microscopy (FLIM) is used, for the first time, to examine fluorescent properties of pigments in melanosomes and evaluate their time evolution upon extended laser irradiation. A relatively short-lived component is discovered in fluorescence emission and significant changes in lifetimes upon irradiation are revealed indicating structural photoinduced changes to melanin occurring on a time scale of minutes, with observations extending up to 1 h.

Indexed as

MelanosomesAnimalsMelaninsMicroscopy, FluorescenceMelaninsfluorescence lifetime imaging microscopylaser‐induced damagemelanosomesphotochemistrypigmentation disorders

Identifiers

PMID40492450
PMCPMC12321278

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.