A Mutation in the Transmembrane Domain of Adenylate Cyclase 3 Impairs Enzymatic Function to Cause Sex-Specific Depression- and Anxiety-Like Behaviors and Food Seeking in a Rat Model.
Mackenzie K Fitzpatrick, Christina Dyson, Angela Beeson, Leighelle Adrian, Glen Marrs, Michael Grzybowski, Jason Klotz, Aron M Geurts, Rong Chen, Jeffrey L Weiner and 1 more
Article in Genes, brain, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Mackenzie K FitzpatrickDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-0107-0169
Christina DysonDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Angela BeesonDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Leighelle AdrianDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Glen MarrsDepartment of Biology, Wake Forest University, Winston-Salem, North Carolina, USA.
Michael GrzybowskiDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jason KlotzDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Aron M GeurtsDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Rong ChenDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-5644-4386
Jeffrey L WeinerDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Leah C Solberg WoodsDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-7943-798X
Funding
Wake Forest Translational Alcohol Research Center (WF-TARC)P50AA026117 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jeffrey L. Weiner · 2018 to 2026
$16.2M
Systems genetics to identify neuronal genes for diet-induced obesityR01DK120667 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOLBERG WOODS, LEAH CATHERINE · 2019 to 2023
$2.9M
Systems Genetics of Adiposity Traits in Outbred RatsR01DK106386 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOLBERG WOODS, LEAH CATHERINE · 2015 to 2018
$2.6M
Ethanol and mGluR2 signalingR01AA030676 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Rong Chen, BRIAN A MCCOOL · 2023 to 2026
$2.2M
The Neurobiology of Drug AbuseT32DA041349 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SARA RAULERSON JONES · 2017 to 2026
$1.8M
Neuroscience Training at Wake ForestT32NS115704 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CZOTY, PAUL W. · 2021 to 2025
$1.4M
Cocaine self-administration and cholesterol metabolismR21DA056857 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHEN, RONG · 2022 to 2023
We have previously demonstrated that a transmembrane domain mutation in Adenylate cyclase 3 (Adcy3) causes increased adiposity and negative emotion-like behaviors in a rat model. We set out to replicate and expand upon our previous study by conducting comprehensive behavioral testing, and we also investigated the molecular changes that result from this mutation. Rats with a mutation in the second transmembrane helix of ADCY3 (Adcy3
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A Mutation in the Transmembrane Domain of Adenylate Cyclase 3 Impairs Enzymatic Function to Cause Sex-Specific Depression- and Anxiety-Like Behaviors and Food Seeking in a Rat Model. · full record | OpenQuestion