ArticleInfection and drug resistance2025
Correlation Between the Distribution of Virulence Genes and Drug Resistance Genes and Clinical Characteristics of Lower Respiratory Tract Infections with
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To analyze the relationship between the distribution of virulence genes and resistance genes and clinical features of lower respiratory tract infections with Methods: Lower respiratory tract specimens from patients with lung infections in the intensive care unit of the Affiliated Hospital of Guizhou Medical University were collected in December 2023, and the study population contained 32 strains of patients with AB infections and 22 strains of patients with KP infections. Target next generation sequencing (tNGS) was used to detect the pathogenic organisms, virulence genes, and drug-resistance genes, and to analyze the changes in the clinical detection indexes of different subgroups of patients. Results: The highest detection rate of Conclusion: The mechanism of virulence of AB and KP is mainly related to affecting bacterial biofilm formation and iron uptake; patients with AB and KP infections in which virulence genes were detected were more likely to be resistant to penicillins, cephalosporins, and carbapenems, among others; patients with pneumoniae infections of KP appeared to be more severe than patients with pneumoniae infections of AB.
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