Evidence map›Paper›PMID 40492154›Full record

ArticleMaterials today. Bio2025

Alkyl side-chain engineering enables significant suppression of conformational relaxation for improved near infrared-II imaging-guided uterine recanalization surgery and cancer phototheranostics.

Meijing Li, Yu Zheng, Zixuan Zhang, Quan Wang, Xiyuan Dong, Zhe Xu, Fayun Ma, Zujin Zhao, Xiaoding Lou, Jun Dai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Meijing LiGuangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541006, China.
Yu ZhengDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.
Zixuan ZhangGuangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541006, China.
Quan WangState Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China.
Xiyuan DongDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.
Zhe XuGuangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541006, China.
Fayun MaGuangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541006, China.
Zujin ZhaoState Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou, 510640, China.
Xiaoding LouState Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China.
Jun DaiDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.
Kezhen LiDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, China.
Shijie ZhenGuangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541006, China.
Ben Zhong TangSchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phototheranostics have recently aroused extreme attention due to its exceptional advantages. Developing a single agent synchronously sharing powerful absorption, high second near-infrared (NIR-II) fluorescence efficiency and photothermal conversion efficiency is urgently demand but extremely scarce. Herein, two kinds of NIR-II phototheranositc agents featuring aggregation-induced emission, NIR-II fluorescence imaging (FLI) and photothermal therapy (PTT) are constructed through constructing electron donor-acceptor (D-A) molecular skeleton with side-chain engineering. Profiting from sufficient molecular rotors, highly twisted configurations, large reorganization energy and high HRf values concentrating stretching/scissoring of alkyl chain, BBT2 is endowed with NIR-II fluorescence property and high photothermal conversion. The nanoparticles (NPs) fabricated with BBT2 exhibit significant NIR-II FLI-guided uterine cavity recanalization surgery and efficient PTT therapy under laser irradiation both in vitro and orthotopic 4T1 mice models. Transvaginal BBT2 NPs are highly effective in assessing uterine cavity patency in mice and the subsequent pregnancy rate with 6 months of follow-up after uterine cavity recanalization surgery is synchronously evaluated.

Indexed as

Near infrared-II fluorescencePhototheranosticSide-chain engineeringUterine recanalization surgery

Identifiers

PMID40492154
PMCPMC12148427

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