ReviewJPRAS open2025
Genetic variants in the development of autoimmune complaints and capsular contracture in women with breast implants: A systematic review.
Review in JPRAS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Breast implants were introduced in 1963 by Cronin and Gerow and are widely used for reconstructive and aesthetic purposes. However, their use has been controversial due to the potential risk of developing autoimmune diseases and surgical complications such as capsular contracture. Currently, no genetic markers have been identified that are definitively associated with these complications. Therefore, we conducted a systematic review to check for the presence of genetic variants that are related to complications such as capsular contracture and autoimmune diseases in women with breast implants. Materials and Methods: A systematic review was conducted following the preferred reporting items for systematic reviews and meta-analyses guidelines. The search included databases such as Web of Science, PubMed, and Scopus, using terms such as "breast implants," "breast prostheses," "genes," "genetic markers," and "autoimmunity." The selected studies were cross-sectional, cohort, and case-control studies that assessed specific genetic variants in women with breast implants and their association with autoimmune diseases or capsular contracture. Results: A total of 6 cross-sectional studies and 1 case-control study were included. The findings related to autoimmune diseases showed a high prevalence of the HLA-DQ10102 variant among women with myositis associated with breast implants compared to women with myositis without implants (81.8% vs. 31.6%; OR 9.8, 95% CI 1.77-96.79). Other studies identified genetic variants associated with capsular contracture, highlighting the expression of MMP, TIMP, TNF-α, and IL-8 genes in severe contractures. Conclusion: Prolonged inflammation and specific genetic variants play a crucial role in the development of capsular contracture and autoimmune diseases in women with breast implants. Identifying these genetic markers could help improve the prediction and management of these complications. However, more longitudinal studies are needed to better understand the mechanisms and validate these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.