Evidence map›Paper›PMID 40492122›Full record

ArticleFrontiers in oncology2025

Signet-ring cell carcinoma in rectal malignancies: a case report with an unexpected outcome.

Aichun Long, Cheng Huang, Qinwei Xu, Shasha He, Li Zhang, Cuiwei Zhang

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aichun LongDepartment of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Cheng HuangDepartment of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Qinwei XuEndoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Shasha HeDepartment of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Li ZhangDepartment of Pathology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Cuiwei ZhangDepartment of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signet ring-like cell prostate cancer is a rare and highly aggressive histological subtype of prostate cancer. The characteristic feature is that the cancer cells produce a large amount of mucin. This mucin gradually accumulates within the cells, pushing the nucleus to one side and giving the cells a signet-ring-like appearance. Late-stage prostate cancer typically metastasizes to bones, lungs, and other organs via lymphatic or hematogenous routes. Rectal involvement with gastrointestinal symptoms as the initial presenting manifestation is relatively uncommon. This case report aims to describe the diagnostic process of prostate cancer in an 82-year-old male patient. The initial symptom was diarrhea, the admission diagnosis was rectal malignancy, and the diagnostic clue was the presence of signet-ring cells. The tumor origin analysis was conducted alongside serological and imaging examinations. Furthermore, this report discusses the endoscopic manifestations, pathomorphological changes, and clinical prognostic analysis of this prostate cancer case, to enhance the recognition of rare pathological subtypes of prostate cancer.

Indexed as

BRAFgenetic testingprostate cancersignet-ring cellsSPOP

Identifiers

PMID40492122
PMCPMC12146205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.