Evidence map›Paper›PMID 40492100›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts.

Alvaro Obeso, Gabin Drouard, Aline Jelenkovic, Juan R Ordoñana, Juan F Sánchez-Romera, Lucía Colodro-Conde, Miina Ollikainen, Sari Aaltonen, Robin P Corley, Brooke M Huibregtse and 37 more

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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

47 authors.

Alvaro ObesoHelsinki Institute for Demography and Population Health, University of Helsinki, Helsinki, Finland.ORCID 0009-0009-1739-0408
Gabin DrouardInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3227-8483
Aline JelenkovicDepartment of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Bilbao, Spain.ORCID 0000-0002-6191-8371
Juan R OrdoñanaDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
Juan F Sánchez-RomeraDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.
Lucía Colodro-CondeDepartment of Human Anatomy and Psychobiology, University of Murcia, Murcia, Spain.ORCID 0000-0002-9004-364X
Miina OllikainenInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3661-7400
Sari AaltonenInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-2873-4263
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.ORCID 0000-0002-2938-4170
Brooke M HuibregtseUniversity of Colorado, Department of Psychology and Neuroscience.ORCID 0000-0003-0977-7249
Emanuela MeddaCentre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0003-4837-4549
Corrado FagnaniCentre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0001-5771-7772
Virgilia ToccaceliCentre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0002-9038-521X
Margaret GatzCenter for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-1071-9970
David A ButlerHealth and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA.
Meike BartelsDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-9667-7555
Lannie LigthartDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-6570-3319
Eco Jc de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0001-6022-2666
Kaare ChristensenInstitute of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-5429-5292
Axel SkyttheInstitute of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-8629-4913
Kirsten O KyvikResearch Unit of Clinical Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark and Odense University Hospital.ORCID 0000-0003-2981-0245
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0003-1382-380X
Scott D GordonQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID 0000-0001-7623-328X
Finn E RasmussenDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Per TyneliusDepartment of Global Public Health, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8155-7406
Carol E FranzDepartment of Psychiatry, University of California, San Diego, CA, USA.ORCID 0000-0002-8987-1755
William S KremenDepartment of Psychiatry, University of California, San Diego, CA, USA.ORCID 0000-0002-8629-5609
Michael J LyonsDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.ORCID 0000-0001-6516-9219
Timothy SpectorDepartment of Twin Research and Genetic epidemiology, King's College, London, UK.
Massimo ManginoDepartment of Twin Research and Genetic epidemiology, King's College, London, UK.ORCID 0000-0002-2167-7470
Genevieve LachanceDepartment of Twin Research and Genetic epidemiology, King's College, London, UK.ORCID 0000-0001-7523-8329
Patrik Ke MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-7315-7899
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8057-3543
Anna K Dahl AslanSchool of Health Sciences, University of Skövde, Skövde, Sweden.ORCID 0000-0002-6305-8993
Glen E DuncanWashington State Twin Registry, Washington State University - Health Sciences Spokane, Spokane, WA, USA.
Dedra BuchwaldWashington State Twin Registry, University of Washington, Seattle, WA, USA.
Hyojin PyunDepartment of Epidemiology, Seoul National University School of Public Health, Seoul, Korea.ORCID 0000-0001-5301-1369
Jooyeon LeeInstitute of Health & Environmental, Seoul National University, Seoul, Korea.
Soo Ji LeeInstitute of Health & Environmental, Seoul National University, Seoul, Korea.
Joohon SungDepartment of Epidemiology, Seoul National University School of Public Health, Seoul, Korea.ORCID 0000-0001-9948-0160
Susanne BruinsDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0001-6808-7075
René PoolDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0001-5579-0933
Anders ErikssoncGEM, Institute of Genomics, University of Tartu, Tartu, Estonia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Dorret I BoomsmaComplex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands.ORCID 0000-0002-7099-7972
Jaakko KaprioInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Karri SilventoinenHelsinki Institute for Demography and Population Health, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1759-3079

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VAUPEL, JAMES W. · 1990 to 2008
$17.5M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Building a Unique National Community Based Twin RepositoryRC2HL103416 · NHLBI · UNIVERSITY OF WASHINGTON · PI BUCHWALD, DEDRA S · 2009 to 2010
$7.7M
The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
DETERMINANTS OF BEHAVIORAL DEVELOPMENT IN CHILDRENR01HD010333 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI WADSWORTH, SALLY J · 1985 to 2010
$3.0M
ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9M
The VETSA Longitudinal Twin Study of Cortisol and AgingR01AG022982 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2004 to 2007
$2.6M
NHLBI NIH HHS RC2 HL103416NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA012502NIA NIH HHS P01 AG008761NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG076838NIA NIH HHS R21 AG039572NICHD NIH HHS R01 HD010333NIDA NIH HHS P60 DA011015Wellcome Trust
6 · The paper itself

Abstract

Introduction: Genetic factors contribute to weight gain, but how these effects change over adulthood is still unknown. We studied the impact of genetics on BMI change from young adulthood to old age and its relationship with BMI in early young adulthood. Data and Methods: Data from 16 longitudinal twin cohorts, including 111,370 adults (56% women) and 55,657 complete twin pairs (42% monozygotic), were pooled. The data were divided into three stages (young adulthood-early middle age, late middle age, and old age). BMI change was calculated using linear mixed effects and delta slope methods. Genetic and environmental contributions to these changes and their correlations with baseline BMI were estimated through structural equation modeling. Results: The average BMI increase per year was 0.18 kg/m Conclusion: Genetics influence BMI change across adulthood, with their impact varying by age and sex. Environmental factors are the main drivers of adult BMI change, highlighting the role of modifiable factors in long-term weight regulation.

Identifiers

PMID40492100
PMCPMC12148285

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