Evidence map›Paper›PMID 40492087›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Respiratory Exacerbations Increase with Chronic PM

James L Crooks, Zhongying Wang, Morteza Karimzadeh, Surya P Bhatt, Craig P Hersh, Dawn L DeMeo, David Baraghoshi, Min Hyung Ryu, Elizabeth A Regan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James L CrooksDivision of Biostatistics and Bioinformatics, National Jewish Health.ORCID 0000-0002-0021-5701
Zhongying WangDepartment of Geography, Institute of Behavioral Science University of Colorado Boulder.ORCID 0000-0002-0207-8202
Morteza KarimzadehDepartment of Geography, Institute of Behavioral Science University of Colorado Boulder.ORCID 0000-0002-6498-1763
Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama Birmingham.ORCID 0000-0002-8418-4497
Craig P HershChanning Division of Network Medicine, Brigham and Women's Hospital & Harvard Medical School.ORCID 0000-0002-1342-4334
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital & Harvard Medical School.ORCID 0000-0001-9653-0636
David BaraghoshiDivision of Biostatistics and Bioinformatics, National Jewish Health.ORCID 0000-0002-9485-9267
Min Hyung RyuDivision of Respiratory Medicine, University of British Columbia.
Elizabeth A ReganDivision of Rheumatology, Department of Medicine, National Jewish Health.ORCID 0000-0003-0624-9184

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
GENETIC EPIDEMIOLOGY OF COPD (COPD GENE) TASK A: STUDY VISIT 4, COLLECTION OF COPDGENE STUDY DATA ANDBIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY75N92023D00011 · NHLBI · NATIONAL JEWISH HEALTH · PI NEWMAN, LEE S · 2023 to 2025
$29.6M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Environmental Factors Predicting Risk of Severe COVID InfectionR21ES032973 · NIEHS · NATIONAL JEWISH HEALTH · PI REGAN, ELIZABETH ANNE · 2021 to 2022
$448k
NHLBI NIH HHS 75N92023D00011NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIEHS NIH HHS R21 ES032973
6 · The paper itself

Abstract

Rationale: Short-term exposure to fine particulates (PM Objectives: To assess long-term effects of PM Methods: A longitudinal cohort of current and former smokers with and without COPD were surveyed every six months for severe exacerbation events. PM Measurements and Main Results: The relative risk of severe exacerbation increased by a factor of 1.516 (CI: 1.226, 1.873; Conclusions: Persistent exposure to fine particulates is a significant risk factor for severe respiratory exacerbations in current and former smokers, and in patients with or at risk of COPD. The effect of fine particulates on the risk of severe exacerbations appears to be greater in those current and former smokers without COPD. The EPA annual PM

Indexed as

air pollutionCOPDexacerbationslong-term exposurePM2.5

Identifiers

PMID40492087
PMCPMC12148289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.