Evidence map›Paper›PMID 40492075›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Prospective Genomic Surveillance of Severe Febrile Illness in Tanzanian Children Identifies High Mortality and Resistance to First-Line Antibiotics in Bloodstream Infections.

Teresa B Kortz, Victoria T Chu, Raya Y Mussa, Erasto M Sunzula, Victoria M Mlele, Cecilia L Msemwa, Lushona K Mathias, Namala P Mkopi, Ryan J Ward, Kathleen S Sun and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Teresa B KortzUniversity of California, San Francisco, California, USA.
Victoria T ChuUniversity of California, San Francisco, California, USA.
Raya Y MussaMuhimbili National Hospital, Dar es Salaam, Tanzania.
Erasto M SunzulaMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Victoria M MleleMuhimbili National Hospital, Dar es Salaam, Tanzania.
Cecilia L MsemwaMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Lushona K MathiasMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Namala P MkopiMuhimbili National Hospital, Dar es Salaam, Tanzania.
Ryan J WardUniversity of California, San Francisco, California, USA.
Kathleen S SunUniversity of California, San Francisco, California, USA.
Jazmin M Baez MaidanaUniversity of California, San Francisco, California, USA.
Anneka M HooftUniversity of California, San Francisco, California, USA.
Juma A MfinangaMuhimbili National Hospital, Dar es Salaam, Tanzania.
Joseph L DeRisiUniversity of California, San Francisco, California, USA.
Hendry R SaweMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Joel P ManyahiMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Charles R LangelierUniversity of California, San Francisco, California, USA.

Funding

Fever Etiology and Prognostic Point-of-Care Biomarkers in African Children with Severe Febrile IllnessK23AI144029 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTZ, TERESA · 2020 to 2024
$984k
Metagenomic surveillance of pathogen and antimicrobial resistance gene transmission in hospitalized neonatesK23AI185326 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHU, VICTORIA TIEN-YU · 2024 to 2025
$395k
NIAID NIH HHS K23 AI144029NIAID NIH HHS K23 AI185326
6 · The paper itself

Abstract

We evaluated the prevalence, pathogen profile, and antimicrobial resistance (AMR) patterns of bloodstream infections (BSIs) among 392 children with severe febrile illness who presented (July 26, 2022-September 20, 2023) to a referral hospital in Tanzania. We identified a causative pathogen in 9.8% (n=38) of participants. Blood culture analysis confirmed BSI in 5.2% (n=20) of participants with a case fatality rate of 45%. Whole genome sequencing (WGS) of blood culture isolates identified gram-negative bacteria (

Indexed as

antimicrobial resistancebloodstream infectionschild healthextended-spectrum beta-lactamasesFebrile illnessgenomic surveillancepediatric infectious diseasessepsiswhole genome sequencing

Identifiers

PMID40492075
PMCPMC12148265

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.