Evidence map›Paper›PMID 40491968›Full record

ArticleMedComm2025

Glycoprotein Ibα-Dependent Platelet Activation is Essential for Tumor Cell-Platelet Interaction and Experimental Metastasis.

Kangxi Zhou, Qing Li, Yue Xia, Chenglin Sun, Jing Wang, Yueyue Sun, Xinxin Ge, Mengnan Yang, Yu Li, Sai Zhang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kangxi ZhouJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Qing LiJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Yue XiaJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Chenglin SunJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Jing WangJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Yueyue SunJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Xinxin GeJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Mengnan YangJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Yu LiJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Sai ZhangJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Lili ZhaoJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Chunliang LiuJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Khan Muhammad ShoaibJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Weiling XiaoJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Renping HuJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Kesheng DaiJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.
Rong YanJiangsu Institute of Hematology The First Affiliated Hospital of Soochow University, Cyrus Tang Medical Institute Suzhou Medical College, Soochow University, NHC Key Laboratory of Thrombosis and Hemostasis, National Clinical Research Center for Hematological Diseases Suzhou Jiangsu China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis is the main cause of cancer-related deaths and the biggest challenge in improving cancer prognosis. Platelet-tumor cell aggregates are a prerequisite for hematogenous metastasis. However, the internal relation and molecular mechanism of platelets and their receptor glycoprotein (GP) Ibα in platelet-tumor cell interaction and metastasis remain elusive. Here, we find that in the absence of the full-length GPIbα or its cytoplasmic tail, platelets maintain a more resting state and exhibit reduced tumor cell-induced platelet activation. The deficiency of the cytoplasmic tail of GPIbα inhibits tumor cell-platelet interaction, platelet-induced tumor cell migration and invasion, and metastasis. Using a state-of-the-art spinning disk intravital microscopy, we observe a rapid accumulation of platelets on tumor cells, forming numerous tumor cell-platelet aggregates in vivo. We also find that the cytoplasmic tail of GPIbα regulates the tumor cell-induced platelet protein kinase C-α (PKCα) activation, and both the pharmacological inhibition and genetic ablation of platelet PKCα attenuate tumor cell-induced platelet activation, tumor cell-platelet interaction, tumor cell migration and invasion, and metastasis. Overall, our findings reveal for the first time that GPIbα promotes experimental metastasis through its cytoplasmic tail-regulated platelet activation, and suggest a potential target to regulate tumor hematogenous metastasis.

Indexed as

glycoprotein Ibαmetastasisplatelet activationtumor cell–platelet interaction

Identifiers

PMID40491968
PMCPMC12146664

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.