Evidence map›Paper›PMID 40491920›Full record

ArticleFrontiers in immunology2025

Demographic characteristics and disease severity associated with IgA/IgG deposition patterns in autoimmune bullous diseases: a cohort study based on a registry database.

Jishu Li, Xun Feng, Mi Wang, Hongjie Liu, Mei Yang, Jiyun Pang, Min Zou, Yue Xiao, Xiwen Zhang, Hongxiang Hu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Jishu Li *Department of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Xun Feng *Department of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Mi WangDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Hongjie LiuDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Mei YangDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, China.
Jiyun PangDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Min ZouDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Yue XiaoDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Xiwen ZhangDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Hongxiang HuDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Yuxi ZhouDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Yazan Moufaq AlqusseireenDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Wei YanDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Xingli ZhouDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Wei LiDepartment of Dermatology and Venereology and Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Direct immunofluorescence (DIF) microscopy is the gold standard for diagnosing autoimmune bullous diseases (AIBDs), but the clinical significance of IgA and IgG co-deposition was unclear. Objective: Investigate the demographic differences and disease severity among different IgG/IgA deposition patterns in DIF. Methods: We conducted a retrospective cohort study based on a registry database that analyzed demographic data, involvement sites, and immunofluorescence patterns of patients with DIF biopsy. Patients were categorized into intercellular (group A) and basement membrane zone (group B) deposition patterns. Logistic regression models assessed associations between deposition status and demographic characteristics. Disease severity and prognosis were analyzed retrospectively through subgroup analyses. Results: In group A, female gender (OR = 1.665, Conclusions: Female gender, stronger IgG deposition, and mucosa tissue are key factors affecting IgA and IgG co-deposition in AIBD patients. For clinical correlation, patients with IgA and IgG co-deposition in pemphigus exhibit more severe disease severity compared with those with IgG deposition only, while patients with co-deposition in pemphigoid are more prone to mucosal involvement.

Indexed as

Autoimmune DiseasesImmunoglobulin AImmunoglobulin GSkin Diseases, VesiculobullousAdultAgedAutoantibodiesCohort StudiesFemaleHumansMaleMiddle AgedRegistriesRetrospective StudiesSeverity of Illness IndexSex FactorsAutoantibodiesImmunoglobulin AImmunoglobulin Gautoimmune bullous diseasedirect immunofluorescenceIgApemphigoidpemphigus

Identifiers

PMID40491920
PMCPMC12146370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.