Evidence map›Paper›PMID 40491915›Full record

ArticleFrontiers in immunology2025

Fungal immunization potentiates CD4

Nitish A Kulkarni, Som G Nanjappa

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nitish A KulkarniDepartment of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL, United States.
Som G NanjappaDepartment of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL, United States.

Funding

Immunity against fungal infectionsR01AI153522 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NANJAPPA, SOMASHEKARAPPA GOWDA · 2021 to 2025
$2.3M
NIAID NIH HHS R01 AI153522
6 · The paper itself

Abstract

The incidence rates of fungal infections are increasing, especially in immunocompromised individuals without an FDA-approved vaccine. Accumulating evidence suggests that T cells are instrumental in providing fungal immunity. An apt stimulation and responses of dendritic cells are pivotal in inducing T-cell responses and vaccine success. Using a mouse model of fungal vaccination, we explored the dynamics, kinetics, activation, and antigen presentation of dendritic cell subsets to unravel the features of dendritic cell responses in the absence of CD4

Indexed as

BlastomycesCD4-Positive T-LymphocytesCross-PrimingDendritic CellsFungal VaccinesAnimalsAntigen PresentationAntigens, FungalFemaleImmunizationLymphocyte ActivationMiceMice, Inbred C57BLAntigens, FungalFungal VaccinesCD4+ T cellsconventional dendritic cellscrosspresentationfungalmigratory dendritic cellsvaccine

Identifiers

PMID40491915
PMCPMC12146322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.