Evidence map›Paper›PMID 40491879›Full record

ArticleWorld journal of critical care medicine2025

Cannabis use disorder and severe sepsis outcomes in cancer patients: Insights from a national inpatient sample.

Avinaash R Sager, Rupak Desai, Maneeth Mylavarapu, Dipsa Shastri, Nikitha Devaprasad, Shiva N Thiagarajan, Deepak Chandramohan, Anshuman Agrawal, Urmi Gada, Akhil Jain

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In one paragraph

Article in World journal of critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Avinaash R SagerInternal Medicine, St. Elizabeth's Medical Center, Boston, MA 02135, United States.
Rupak DesaiOutcomes Research, Independent Researcher, Atlanta, GA 30033, United States.
Maneeth MylavarapuPublic Health, Adelphi University, Garden City, NY 11530, United States.
Dipsa ShastriInternal Medicine, East Tennessee State University, Johnson, TN 37614, United States.
Nikitha DevaprasadInternal Medicine, SRM Medical College Hospital and Research Center, Potheri 603211, India.
Shiva N ThiagarajanInternal Medicine, SRM Medical College Hospital and Research Center, Potheri 603211, India.
Deepak ChandramohanDepartment of Nephrology, University of Alabama at Birmingham, Birmingham, AL 35001, United States.
Anshuman AgrawalInternal Medicine, Kasturba Hospital, Manipal 576104, India.
Urmi GadaInfectious Diseases, Deenanath Hospital, Erandwane 411004, India.
Akhil JainDepartment of Hematology and Medical Oncology, University of Iowa Hospitals and Clinics, Iowa, IA 52242, United States. akhiljaindr@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe burden of cannabis use disorder (CUD) in the context of its prevalence and subsequent cardiopulmonary outcomes among cancer patients with severe sepsis is unclear.

aimTo address this knowledge gap, especially due to rising patterns of cannabis use and its emerging pharmacological role in cancer.

methodsBy applying relevant International Classification of Diseases, Ninth and Tenth Revision, Clinical Modification codes to the National Inpatient Sample database between 2016-2020, we identified CUD(+) and CUD(-) arms among adult cancer admissions with severe sepsis. Comparing the two cohorts, we examined baseline demographic characteristics, epidemiological trends, major adverse cardiac and cerebrovascular events, respiratory failure, hospital cost, and length of stay. We used the Pearson

resultsWe identified a total of 743520 cancer patients admitted with severe sepsis, of which 4945 had CUD. Demographically, the CUD(+) cohort was more likely to be younger (median age = 58

conclusionCUD(+) cancer patients with severe sepsis, who tended to be younger, black, males with higher rates of substance use and depression had paradoxically significantly lower odds of all-cause in-hospital mortality and respiratory failure. Future research should aim to better elucidate the underlying mechanisms for these observations.

Indexed as

CancerCannabis/marijuanaCardiovascular outcomesMajor adverse cardiac and cerebrovascular eventsPulmonological complicationsSepsis

Identifiers

PMID40491879
PMCPMC11891851

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.