Evidence map›Paper›PMID 40491856›Full record

ArticleEuropean journal of obstetrics & gynecology and reproductive biology: X2025

Risk factors of recurrent cervical intraepithelial neoplasm 2/3 after primary excisional conization/LEEP treatments: A follow-up nationwide cohort study.

Hung Shen, Mei-Hsuan Wu, Jian-Jhih Lin, Heng-Cheng Hsu, Yi-Jou Tai, Chia-Ying Wu, Chia-Yi Lee, Yen-Han Wang, Ying-Cheng Chiang

Abstract read
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In one paragraph

Article in European journal of obstetrics & gynecology and reproductive biology: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hung ShenDepartment of Obstetrics and Gynecology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Mei-Hsuan WuDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Jian-Jhih LinDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Heng-Cheng HsuDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yi-Jou TaiDepartment of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chia-Ying WuDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Chia-Yi LeeDepartment of Obstetrics and Gynecology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Yen-Han WangDepartment of Obstetrics and Gynecology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Ying-Cheng ChiangDepartment of Obstetrics and Gynecology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Follow-up human papillomavirus (HPV) testing 6 months after treatment is suggested for women with cervical intraepithelial neoplasm (CIN) 2/3. However, the Pap smear remains the only feasible tool in areas with limited resources. Our study aimed to evaluate the risk factors of recurrent CIN2/3 after excision treatment by follow-up Pap smear in a nationwide database. Methods: We retrospectively identified women receiving excision treatment for CIN2/3 from 2007 to 2016 in the Taiwan National Cervical Cancer Screening Database. Risk factors of recurrence including age, education status, follow-up frequency, and the results of serial follow-up Pap smears were analyzed. Results: In total, 11595 women were enrolled, 287 having recurrent CIN2 + diseases (cumulative incidence of recurrence of 24.8/1000 people). The incidence of recurrent CIN2 + lesions was highest in the over 60-year-old age group (12.12/1000 person-years). For the first follow-up Pap smear, the highest recurrence rate was in the AGC/HSIL+ group (106.6/1000 people). Multivariate Cox regression analysis revealed that over 60 years of age, AGC/HSIL+ in the first follow-up pap smear, and any abnormal pap smear result within the first year after treatment were risk factors of CIN2/3 recurrence. Conclusions: In patients receiving excision for CIN2/3, the recurrence risk was higher in patients older than 60 years of age, and who had any abnormal follow-up Pap smear results, especially AGC/HSIL+ , in the first year after treatment.

Indexed as

Cervical intraepithelial neoplasmConizationLEEPRecurrence

Identifiers

PMID40491856
PMCPMC12148459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.