ArticleInternational journal of nanomedicine2025
Poly-Lysine-Derived Carbon Quantum Dots Promote the Repair of Bone Defects in Osteomyelitis Through Antibacterial and Osteogenic Effects.
Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Osteomyelitis is a challenging clinical condition to manage effectively. In this study, we used ε-Poly (L-lysine) as the raw material to synthesize carbon quantum dots (PL-CQDs). These PL-CQDs possess antibacterial and osteogenesis ability, and are expected to improve the therapeutic effect of osteomyelitis. Methods: PL-CQDs were synthesized via a dry heat-intermittent ultrasound method and characterized. The antibacterial efficacy of PL-CQDs was assessed using the spread plate method. The biological functions of PL-CQDs were evaluated through CCK-8 assays, scratch wound healing assay, osteogenic differentiation experiments, and transcriptome sequencing. In the in vivo experiments, the rats with osteomyelitis were evenly divided into five groups and treated with calcium sulfate containing different concentrations of PL-CQDs, and the therapeutic effects were evaluated by micro-CT and histology. Results: PL-CQDs at concentrations of 200, 400, and 800 µg/mL exhibited no cytotoxicity and demonstrated the ability to kill methicillin-resistant Conclusion: PL-CQDs exhibit antibacterial and osteogenic properties and may serve as a potential alternative treatment for osteomyelitis.
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